The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2

Background. We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression. Methods and Results. 40 elective CABG patients were allocated into two groups. The adenosine group (n = 20) received 250 μg/kg adenosine into the aortic root followed by blood...

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Autores principales: Shalaby, Ahmed, Rinne, Timo, Järvinen, Otso, Latva-Hirvelä, Juha, Nuutila, Kristiina, Saraste, Antti, Laurikka, Jari, Porkkala, Helena, Saukko, Pekka, Tarkka, Matti
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2009
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801008/
https://www.ncbi.nlm.nih.gov/pubmed/20069048
http://dx.doi.org/10.4061/2009/658965
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author Shalaby, Ahmed
Rinne, Timo
Järvinen, Otso
Latva-Hirvelä, Juha
Nuutila, Kristiina
Saraste, Antti
Laurikka, Jari
Porkkala, Helena
Saukko, Pekka
Tarkka, Matti
author_facet Shalaby, Ahmed
Rinne, Timo
Järvinen, Otso
Latva-Hirvelä, Juha
Nuutila, Kristiina
Saraste, Antti
Laurikka, Jari
Porkkala, Helena
Saukko, Pekka
Tarkka, Matti
author_sort Shalaby, Ahmed
collection PubMed
description Background. We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression. Methods and Results. 40 elective CABG patients were allocated into two groups. The adenosine group (n = 20) received 250 μg/kg adenosine into the aortic root followed by blood potassium cardioplegia. The control group received potassium cardioplegia in blood. Bcl-2 and bax were measured. Bax was reduced in the postoperative biopsies (1.38 versus 0.47, P = .002) in the control group. Bcl-2 showed a reducing tendency (0.14 versus 0.085, P = .07). After the adenosine treatment, the expression of both bax (0.52 versus 0.59, P = .4) and bcl-2 (0.104 versus 0.107, P = .4) remained unaltered after the operation. Conclusion. Open heart surgery is associated with rapid reduction in the expression of apoptosis regulating genes bax and bcl-2. Fast Adenosine induction abolished changes in their expression.
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spelling pubmed-28010082010-01-12 The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2 Shalaby, Ahmed Rinne, Timo Järvinen, Otso Latva-Hirvelä, Juha Nuutila, Kristiina Saraste, Antti Laurikka, Jari Porkkala, Helena Saukko, Pekka Tarkka, Matti Cardiol Res Pract Clinical Study Background. We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression. Methods and Results. 40 elective CABG patients were allocated into two groups. The adenosine group (n = 20) received 250 μg/kg adenosine into the aortic root followed by blood potassium cardioplegia. The control group received potassium cardioplegia in blood. Bcl-2 and bax were measured. Bax was reduced in the postoperative biopsies (1.38 versus 0.47, P = .002) in the control group. Bcl-2 showed a reducing tendency (0.14 versus 0.085, P = .07). After the adenosine treatment, the expression of both bax (0.52 versus 0.59, P = .4) and bcl-2 (0.104 versus 0.107, P = .4) remained unaltered after the operation. Conclusion. Open heart surgery is associated with rapid reduction in the expression of apoptosis regulating genes bax and bcl-2. Fast Adenosine induction abolished changes in their expression. SAGE-Hindawi Access to Research 2009 2009-12-22 /pmc/articles/PMC2801008/ /pubmed/20069048 http://dx.doi.org/10.4061/2009/658965 Text en Copyright © 2009 Ahmed Shalaby et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Shalaby, Ahmed
Rinne, Timo
Järvinen, Otso
Latva-Hirvelä, Juha
Nuutila, Kristiina
Saraste, Antti
Laurikka, Jari
Porkkala, Helena
Saukko, Pekka
Tarkka, Matti
The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2
title The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2
title_full The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2
title_fullStr The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2
title_full_unstemmed The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2
title_short The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2
title_sort impact of adenosine fast induction of myocardial arrest during cabg on myocardial expression of apoptosis-regulating genes bax and bcl-2
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801008/
https://www.ncbi.nlm.nih.gov/pubmed/20069048
http://dx.doi.org/10.4061/2009/658965
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