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Mizoribine: A New Approach in the Treatment of Renal Disease
Mizoribine (MZB) is an imidazole nucleoside and an immunosuppressive agent. The immunosuppressive effect of MZB has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. Because of its relative lack of toxicity, during the past decade MZB has been frequently us...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801010/ https://www.ncbi.nlm.nih.gov/pubmed/20052390 http://dx.doi.org/10.1155/2009/681482 |
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author | Kawasaki, Yukihiko |
author_facet | Kawasaki, Yukihiko |
author_sort | Kawasaki, Yukihiko |
collection | PubMed |
description | Mizoribine (MZB) is an imidazole nucleoside and an immunosuppressive agent. The immunosuppressive effect of MZB has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. Because of its relative lack of toxicity, during the past decade MZB has been frequently used instead of azathioprine as a component of immunosuppressive drug regimens. MZB is being used to treat renal transplantation patients, IgA nephropathy, lupus erythematosus, and childhood nephrotic syndrome (NS), and some recent studies have assessed the efficacy of oral MZB pulse therapy for severe lupus nephritis, steroid-resistant NS, and frequently relapsing-steroid-dependent NS. This review summarizes the published findings on the efficacy of MZB for renal disease including IgA nephropathy, lupus nephritis, and NS, as well as of oral MZB pulse therapy for severe lupus nephritis and NS, and also the mechanism of the effect of oral MZB pulse therapy on the lymphocyte cell cycle. |
format | Text |
id | pubmed-2801010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28010102010-01-05 Mizoribine: A New Approach in the Treatment of Renal Disease Kawasaki, Yukihiko Clin Dev Immunol Review Article Mizoribine (MZB) is an imidazole nucleoside and an immunosuppressive agent. The immunosuppressive effect of MZB has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. Because of its relative lack of toxicity, during the past decade MZB has been frequently used instead of azathioprine as a component of immunosuppressive drug regimens. MZB is being used to treat renal transplantation patients, IgA nephropathy, lupus erythematosus, and childhood nephrotic syndrome (NS), and some recent studies have assessed the efficacy of oral MZB pulse therapy for severe lupus nephritis, steroid-resistant NS, and frequently relapsing-steroid-dependent NS. This review summarizes the published findings on the efficacy of MZB for renal disease including IgA nephropathy, lupus nephritis, and NS, as well as of oral MZB pulse therapy for severe lupus nephritis and NS, and also the mechanism of the effect of oral MZB pulse therapy on the lymphocyte cell cycle. Hindawi Publishing Corporation 2009 2009-12-13 /pmc/articles/PMC2801010/ /pubmed/20052390 http://dx.doi.org/10.1155/2009/681482 Text en Copyright © 2009 Yukihiko Kawasaki. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kawasaki, Yukihiko Mizoribine: A New Approach in the Treatment of Renal Disease |
title | Mizoribine: A New Approach in the Treatment of Renal Disease |
title_full | Mizoribine: A New Approach in the Treatment of Renal Disease |
title_fullStr | Mizoribine: A New Approach in the Treatment of Renal Disease |
title_full_unstemmed | Mizoribine: A New Approach in the Treatment of Renal Disease |
title_short | Mizoribine: A New Approach in the Treatment of Renal Disease |
title_sort | mizoribine: a new approach in the treatment of renal disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801010/ https://www.ncbi.nlm.nih.gov/pubmed/20052390 http://dx.doi.org/10.1155/2009/681482 |
work_keys_str_mv | AT kawasakiyukihiko mizoribineanewapproachinthetreatmentofrenaldisease |