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NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats

The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months sign...

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Autores principales: Park, Sung-Hoon, Dutta, Noton Kumar, Baek, Min-Won, Kim, Dong-Jae, Na, Yi-Rang, Seok, Seung-Hyeok, Lee, Byoung-Hee, Cho, Ji-Eun, Cho, Geon-Sik, Park, Jae-Hak
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801110/
https://www.ncbi.nlm.nih.gov/pubmed/19461209
http://dx.doi.org/10.4142/jvs.2009.10.2.141
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author Park, Sung-Hoon
Dutta, Noton Kumar
Baek, Min-Won
Kim, Dong-Jae
Na, Yi-Rang
Seok, Seung-Hyeok
Lee, Byoung-Hee
Cho, Ji-Eun
Cho, Geon-Sik
Park, Jae-Hak
author_facet Park, Sung-Hoon
Dutta, Noton Kumar
Baek, Min-Won
Kim, Dong-Jae
Na, Yi-Rang
Seok, Seung-Hyeok
Lee, Byoung-Hee
Cho, Ji-Eun
Cho, Geon-Sik
Park, Jae-Hak
author_sort Park, Sung-Hoon
collection PubMed
description The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.
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spelling pubmed-28011102010-01-11 NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats Park, Sung-Hoon Dutta, Noton Kumar Baek, Min-Won Kim, Dong-Jae Na, Yi-Rang Seok, Seung-Hyeok Lee, Byoung-Hee Cho, Ji-Eun Cho, Geon-Sik Park, Jae-Hak J Vet Sci Original Article The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made. The Korean Society of Veterinary Science 2009-06 2009-06-11 /pmc/articles/PMC2801110/ /pubmed/19461209 http://dx.doi.org/10.4142/jvs.2009.10.2.141 Text en Copyright © 2009 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Sung-Hoon
Dutta, Noton Kumar
Baek, Min-Won
Kim, Dong-Jae
Na, Yi-Rang
Seok, Seung-Hyeok
Lee, Byoung-Hee
Cho, Ji-Eun
Cho, Geon-Sik
Park, Jae-Hak
NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats
title NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats
title_full NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats
title_fullStr NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats
title_full_unstemmed NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats
title_short NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats
title_sort nacl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801110/
https://www.ncbi.nlm.nih.gov/pubmed/19461209
http://dx.doi.org/10.4142/jvs.2009.10.2.141
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