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Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infe...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Society of Veterinary Science
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801129/ https://www.ncbi.nlm.nih.gov/pubmed/19687616 http://dx.doi.org/10.4142/jvs.2009.10.3.177 |
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author | Lee, Juyeon Moon, Changjong Kim, Jihoon Jung, Chanwoo Lee, Keun-Hwa Joo, Hong-Gu Ahn, Meejung Shin, Taekyun |
author_facet | Lee, Juyeon Moon, Changjong Kim, Jihoon Jung, Chanwoo Lee, Keun-Hwa Joo, Hong-Gu Ahn, Meejung Shin, Taekyun |
author_sort | Lee, Juyeon |
collection | PubMed |
description | The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms. |
format | Text |
id | pubmed-2801129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28011292010-01-11 Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine Lee, Juyeon Moon, Changjong Kim, Jihoon Jung, Chanwoo Lee, Keun-Hwa Joo, Hong-Gu Ahn, Meejung Shin, Taekyun J Vet Sci Original Article The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms. The Korean Society of Veterinary Science 2009-09 2009-09-07 /pmc/articles/PMC2801129/ /pubmed/19687616 http://dx.doi.org/10.4142/jvs.2009.10.3.177 Text en Copyright © 2009 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Juyeon Moon, Changjong Kim, Jihoon Jung, Chanwoo Lee, Keun-Hwa Joo, Hong-Gu Ahn, Meejung Shin, Taekyun Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine |
title | Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine |
title_full | Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine |
title_fullStr | Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine |
title_full_unstemmed | Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine |
title_short | Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine |
title_sort | immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801129/ https://www.ncbi.nlm.nih.gov/pubmed/19687616 http://dx.doi.org/10.4142/jvs.2009.10.3.177 |
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