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Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine

The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infe...

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Autores principales: Lee, Juyeon, Moon, Changjong, Kim, Jihoon, Jung, Chanwoo, Lee, Keun-Hwa, Joo, Hong-Gu, Ahn, Meejung, Shin, Taekyun
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801129/
https://www.ncbi.nlm.nih.gov/pubmed/19687616
http://dx.doi.org/10.4142/jvs.2009.10.3.177
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author Lee, Juyeon
Moon, Changjong
Kim, Jihoon
Jung, Chanwoo
Lee, Keun-Hwa
Joo, Hong-Gu
Ahn, Meejung
Shin, Taekyun
author_facet Lee, Juyeon
Moon, Changjong
Kim, Jihoon
Jung, Chanwoo
Lee, Keun-Hwa
Joo, Hong-Gu
Ahn, Meejung
Shin, Taekyun
author_sort Lee, Juyeon
collection PubMed
description The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms.
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spelling pubmed-28011292010-01-11 Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine Lee, Juyeon Moon, Changjong Kim, Jihoon Jung, Chanwoo Lee, Keun-Hwa Joo, Hong-Gu Ahn, Meejung Shin, Taekyun J Vet Sci Original Article The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms. The Korean Society of Veterinary Science 2009-09 2009-09-07 /pmc/articles/PMC2801129/ /pubmed/19687616 http://dx.doi.org/10.4142/jvs.2009.10.3.177 Text en Copyright © 2009 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Juyeon
Moon, Changjong
Kim, Jihoon
Jung, Chanwoo
Lee, Keun-Hwa
Joo, Hong-Gu
Ahn, Meejung
Shin, Taekyun
Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
title Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
title_full Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
title_fullStr Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
title_full_unstemmed Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
title_short Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
title_sort immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801129/
https://www.ncbi.nlm.nih.gov/pubmed/19687616
http://dx.doi.org/10.4142/jvs.2009.10.3.177
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