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A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants

BACKGROUND: Diverse environmental contaminants, including the plasticizer di(2-ethylhexyl)phthalate (DEHP), are hepatocarcinogenic peroxisome proliferators in rodents. Peroxisome proliferator–activated receptor-α (PPAR-α) activation and its sequelae have been proposed to constitute a mode of action...

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Detalles Bibliográficos
Autores principales:	Guyton, Kathryn Z., Chiu, Weihsueh A., Bateson, Thomas F., Jinot, Jennifer, Scott, Cheryl Siegel, Brown, Rebecca C., Caldwell, Jane C.
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2009
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801168/ https://www.ncbi.nlm.nih.gov/pubmed/20049115 http://dx.doi.org/10.1289/ehp.0900758

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