Integration of a Phosphatase Cascade with the Mitogen-activated Protein Kinase Pathway Provides for a Novel Signal Processing Function

We mathematically modeled the receptor-dependent mitogen-activated protein kinase (MAPK) signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAPK pathway. A novel regulatory motif was, thus, generated...

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Detalles Bibliográficos
Autores principales: Chaudhri, Virendra K., Kumar, Dhiraj, Misra, Manjari, Dua, Raina, Rao, Kanury V. S.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Biomolecular Networks
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801257/
https://www.ncbi.nlm.nih.gov/pubmed/19897477
http://dx.doi.org/10.1074/jbc.M109.055863

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