Cargando…
A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer
We have previously shown that the C-glycoside analog of α-galactosylceramide (α-GalCer), α-C-GalCer, displays a superior inhibitory activity against the liver stages of the rodent malaria parasite Plasmodium yoelii than its parental glycolipid, α-GalCer. In this study, we demonstrate that NK cells,...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801455/ https://www.ncbi.nlm.nih.gov/pubmed/20069056 http://dx.doi.org/10.1155/2010/283612 |
_version_ | 1782175922796888064 |
---|---|
author | Schmieg, John Yang, Guangli Franck, Richard W. Tsuji, Moriya |
author_facet | Schmieg, John Yang, Guangli Franck, Richard W. Tsuji, Moriya |
author_sort | Schmieg, John |
collection | PubMed |
description | We have previously shown that the C-glycoside analog of α-galactosylceramide (α-GalCer), α-C-GalCer, displays a superior inhibitory activity against the liver stages of the rodent malaria parasite Plasmodium yoelii than its parental glycolipid, α-GalCer. In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by α-C-GalCer. Surprisingly, the diminished production of Th2 cytokines, including IL-4, by α-C-GalCer has no affect on its superior therapeutic activity relative to α-GalCer. Finally, we show that the in vivo administration of α-C-GalCer induces prolonged maturation of dendritic cells (DCs), as well as an enhanced proliferative response of mouse invariant Vα14 (Vα14i) NKT cells, both of which may also contribute to some degree to the superior activity of α-C-GalCer in vivo. |
format | Text |
id | pubmed-2801455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28014552010-01-12 A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer Schmieg, John Yang, Guangli Franck, Richard W. Tsuji, Moriya J Biomed Biotechnol Research Article We have previously shown that the C-glycoside analog of α-galactosylceramide (α-GalCer), α-C-GalCer, displays a superior inhibitory activity against the liver stages of the rodent malaria parasite Plasmodium yoelii than its parental glycolipid, α-GalCer. In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by α-C-GalCer. Surprisingly, the diminished production of Th2 cytokines, including IL-4, by α-C-GalCer has no affect on its superior therapeutic activity relative to α-GalCer. Finally, we show that the in vivo administration of α-C-GalCer induces prolonged maturation of dendritic cells (DCs), as well as an enhanced proliferative response of mouse invariant Vα14 (Vα14i) NKT cells, both of which may also contribute to some degree to the superior activity of α-C-GalCer in vivo. Hindawi Publishing Corporation 2010 2009-12-27 /pmc/articles/PMC2801455/ /pubmed/20069056 http://dx.doi.org/10.1155/2010/283612 Text en Copyright © 2010 John Schmieg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Schmieg, John Yang, Guangli Franck, Richard W. Tsuji, Moriya A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer |
title | A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer |
title_full | A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer |
title_fullStr | A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer |
title_full_unstemmed | A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer |
title_short | A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer |
title_sort | multifactorial mechanism in the superior antimalarial activity of α-c-galcer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801455/ https://www.ncbi.nlm.nih.gov/pubmed/20069056 http://dx.doi.org/10.1155/2010/283612 |
work_keys_str_mv | AT schmiegjohn amultifactorialmechanisminthesuperiorantimalarialactivityofacgalcer AT yangguangli amultifactorialmechanisminthesuperiorantimalarialactivityofacgalcer AT franckrichardw amultifactorialmechanisminthesuperiorantimalarialactivityofacgalcer AT tsujimoriya amultifactorialmechanisminthesuperiorantimalarialactivityofacgalcer AT schmiegjohn multifactorialmechanisminthesuperiorantimalarialactivityofacgalcer AT yangguangli multifactorialmechanisminthesuperiorantimalarialactivityofacgalcer AT franckrichardw multifactorialmechanisminthesuperiorantimalarialactivityofacgalcer AT tsujimoriya multifactorialmechanisminthesuperiorantimalarialactivityofacgalcer |