Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo...

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Detalles Bibliográficos
Autores principales: Van de Velde, Sébastien, Carryn, Stéphane, Van Bambeke, Françoise, Hill, Colin, Tulkens, Paul M, Sleator, Roy D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801671/
https://www.ncbi.nlm.nih.gov/pubmed/20003484
http://dx.doi.org/10.1186/1757-4749-1-23
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author Van de Velde, Sébastien
Carryn, Stéphane
Van Bambeke, Françoise
Hill, Colin
Tulkens, Paul M
Sleator, Roy D
author_facet Van de Velde, Sébastien
Carryn, Stéphane
Van Bambeke, Françoise
Hill, Colin
Tulkens, Paul M
Sleator, Roy D
author_sort Van de Velde, Sébastien
collection PubMed
description While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.
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spelling pubmed-28016712010-01-05 Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes Van de Velde, Sébastien Carryn, Stéphane Van Bambeke, Françoise Hill, Colin Tulkens, Paul M Sleator, Roy D Gut Pathog Short Report While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem. BioMed Central 2009-12-15 /pmc/articles/PMC2801671/ /pubmed/20003484 http://dx.doi.org/10.1186/1757-4749-1-23 Text en Copyright ©2009 Van de Velde et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Van de Velde, Sébastien
Carryn, Stéphane
Van Bambeke, Françoise
Hill, Colin
Tulkens, Paul M
Sleator, Roy D
Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
title Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
title_full Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
title_fullStr Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
title_full_unstemmed Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
title_short Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes
title_sort penicillin-binding proteins (pbp) and lmo0441 (a pbp-like protein) play a role in beta-lactam sensitivity of listeria monocytogenes
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801671/
https://www.ncbi.nlm.nih.gov/pubmed/20003484
http://dx.doi.org/10.1186/1757-4749-1-23
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