Cargando…

The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation

To cause disease, cholera toxin (CT) is transported from the cell surface to the endoplasmic reticulum (ER) lumen where the catalytic CTA1 subunit retro-translocates to the cytosol to induce pathological water secretion. Two retro-translocon components are the Derlins and ER-associated multi-spannin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernardi, Kaleena M., Williams, Jeffrey M., Kikkert, Marjolein, van Voorden, Sjaak, Wiertz, Emmanuel J., Ye, Yihong, Tsai, Billy
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801707/ https://www.ncbi.nlm.nih.gov/pubmed/19864457 http://dx.doi.org/10.1091/mbc.E09-07-0586

Ejemplares similares

The Ero1α-PDI Redox Cycle Regulates Retro-Translocation of Cholera Toxin
por: Moore, Paul, et al.
Publicado: (2010)

SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78
por: Khodayari, Nazli, et al.
Publicado: (2017)

A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates
por: Bernardi, Kaleena M., et al.
Publicado: (2013)

Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1
por: Ye, Yilin, et al.
Publicado: (2018)

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum
por: Zhang, Ting, et al.
Publicado: (2015)

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
por: Menzies, Sam A, et al.
Publicado: (2018)

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase
por: Fu, Min, et al.
Publicado: (2013)

Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis
por: Joshi, Vibhuti, et al.
Publicado: (2017)

Putative Interaction Proteins of the Ubiquitin Ligase Hrd1 in Magnaporthe oryzae
por: Jiang, Haolang, et al.
Publicado: (2018)

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1
por: Peterson, Brian G, et al.
Publicado: (2019)

Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases
por: Wang, Ying, et al.
Publicado: (2013)

USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase
por: Harada, Kumi, et al.
Publicado: (2016)

Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation
por: Shao, Jia, et al.
Publicado: (2014)

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase
por: Rubenstein, Eric M., et al.
Publicado: (2012)

E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation
por: Liu, Liu, et al.
Publicado: (2020)

Effects of Oxidative Stress on the Solubility of HRD1, a Ubiquitin Ligase Implicated in Alzheimer’s Disease
por: Saito, Ryo, et al.
Publicado: (2014)

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity
por: Xu, Yuanming, et al.
Publicado: (2016)

Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP
por: Yang, Hui, et al.
Publicado: (2010)

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
por: Wei, Juncheng, et al.
Publicado: (2018)

Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer
por: Zhang, Tianpeng, et al.
Publicado: (2015)

E3 ubiquitin ligase HRD1 modulates the circadian clock through regulation of BMAL1 stability
por: Guo, Dongkai, et al.
Publicado: (2020)

Disulfide-crosslink analysis of the ubiquitin ligase Hrd1 complex during endoplasmic reticulum-associated protein degradation
por: Pisa, Rudolf, et al.
Publicado: (2022)

Establishment of an In Vitro Transport Assay That Reveals Mechanistic Differences in Cytosolic Events Controlling Cholera Toxin and T-Cell Receptor α Retro-Translocation
por: Moore, Paul, et al.
Publicado: (2013)

p38 MAP kinase–dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER–mitochondria association and mitochondria motility
por: Li, Lei, et al.
Publicado: (2015)

Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program
por: Kim, Hyunbae, et al.
Publicado: (2021)

Host E3 ligase Hrd1 ubiquitinates and degrades H protein of canine distemper virus to inhibit viral replication
por: Wang, Wenjie, et al.
Publicado: (2023)

Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase
por: Jo, Youngah, et al.
Publicado: (2011)

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates
por: Zattas, Dimitrios, et al.
Publicado: (2013)

Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers
por: Oudshoorn, Diede, et al.
Publicado: (2012)

Functional Role of RING Ubiquitin E3 Ligase VdBre1 and VdHrd1 in the Pathogenicity and Penetration Structure Formation of Verticillium dahliae
por: Yang, Xing, et al.
Publicado: (2023)

Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race
por: Singhal, Sandeep K., et al.
Publicado: (2022)

Implementing HRD technology /
Publicado: (1999)

The Host E3-Ubiquitin Ligase TRIM28 Impedes Viral Protein GP4 Ubiquitination and Promotes PRRSV Replication
por: Cui, Zhiying, et al.
Publicado: (2023)

SIMPLE/LITAF Expression Induces the Translocation of the Ubiquitin Ligase Itch towards the Lysosomal Compartments
por: Eaton, Heather E., et al.
Publicado: (2011)

The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response
por: van Huizen, Mariska, et al.
Publicado: (2020)

The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein
por: van de Weijer, Michael L., et al.
Publicado: (2016)

Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins
por: Cho, Jin A., et al.
Publicado: (2012)

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation
por: Liu, Yanfen, et al.
Publicado: (2014)

Ubiquitin ligases and beyond
por: Dikic, Ivan, et al.
Publicado: (2012)

Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
por: Schoebel, Stefan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c5vcrg9f6jektfi9ohnolgub9g