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Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments

BACKGROUND: Progressive loss of articular cartilage is a central hallmark in many joint disease, however, the relative importance of individual proteolytic pathways leading to cartilage erosion is at present unknown. We therefore investigated the time-dependant release ex vivo of MMP- and aggrecanas...

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Detalles Bibliográficos
Autores principales:	Wang, Bijue, Chen, Pingping, Jensen, Anne-Christine Bay, Karsdal, Morten A, Madsen, Suzi H, Sondergaard, Bodil-Cecilie, Zheng, Qinlong, Qvist, Per
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803187/ https://www.ncbi.nlm.nih.gov/pubmed/20021645 http://dx.doi.org/10.1186/1756-0500-2-259

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