Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

BACKGROUND: Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood. CASE PRESENTATION: We report the firs...

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Autores principales: Malvy, Denis, Ezzedine, Khaled, Mamani-Matsuda, Maria, Autran, Brigitte, Tolou, Hugues, Receveur, Marie-Catherine, Pistone, Thierry, Rambert, Jérome, Moynet, Daniel, Mossalayi, Djavad
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803790/
https://www.ncbi.nlm.nih.gov/pubmed/20003320
http://dx.doi.org/10.1186/1471-2334-9-200
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author Malvy, Denis
Ezzedine, Khaled
Mamani-Matsuda, Maria
Autran, Brigitte
Tolou, Hugues
Receveur, Marie-Catherine
Pistone, Thierry
Rambert, Jérome
Moynet, Daniel
Mossalayi, Djavad
author_facet Malvy, Denis
Ezzedine, Khaled
Mamani-Matsuda, Maria
Autran, Brigitte
Tolou, Hugues
Receveur, Marie-Catherine
Pistone, Thierry
Rambert, Jérome
Moynet, Daniel
Mossalayi, Djavad
author_sort Malvy, Denis
collection PubMed
description BACKGROUND: Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood. CASE PRESENTATION: We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection. CONCLUSIONS: Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.
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spelling pubmed-28037902010-01-10 Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies Malvy, Denis Ezzedine, Khaled Mamani-Matsuda, Maria Autran, Brigitte Tolou, Hugues Receveur, Marie-Catherine Pistone, Thierry Rambert, Jérome Moynet, Daniel Mossalayi, Djavad BMC Infect Dis Case Report BACKGROUND: Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood. CASE PRESENTATION: We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection. CONCLUSIONS: Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease. BioMed Central 2009-12-10 /pmc/articles/PMC2803790/ /pubmed/20003320 http://dx.doi.org/10.1186/1471-2334-9-200 Text en Copyright ©2009 Malvy et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Malvy, Denis
Ezzedine, Khaled
Mamani-Matsuda, Maria
Autran, Brigitte
Tolou, Hugues
Receveur, Marie-Catherine
Pistone, Thierry
Rambert, Jérome
Moynet, Daniel
Mossalayi, Djavad
Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
title Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
title_full Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
title_fullStr Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
title_full_unstemmed Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
title_short Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
title_sort destructive arthritis in a patient with chikungunya virus infection with persistent specific igm antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803790/
https://www.ncbi.nlm.nih.gov/pubmed/20003320
http://dx.doi.org/10.1186/1471-2334-9-200
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