Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report

We describe an autopsy case of non-functioning pancreatic neuroendocrine carcinoma metastasizing to the myocardium. A 63-year-old Japanese man was admitted to the hospital presenting with dyspnea. Echocardiography revealed marked left ventricular hypertrophy and diffuse myocardial thickening with pe...

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Autores principales: Kondo, Takeshi, Kitazawa, Riko, Kawata, Emiko, Mori, Kiyoshi, Kitazawa, Sohei
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803924/
https://www.ncbi.nlm.nih.gov/pubmed/20062644
http://dx.doi.org/10.1186/1757-1626-2-9127
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author Kondo, Takeshi
Kitazawa, Riko
Kawata, Emiko
Mori, Kiyoshi
Kitazawa, Sohei
author_facet Kondo, Takeshi
Kitazawa, Riko
Kawata, Emiko
Mori, Kiyoshi
Kitazawa, Sohei
author_sort Kondo, Takeshi
collection PubMed
description We describe an autopsy case of non-functioning pancreatic neuroendocrine carcinoma metastasizing to the myocardium. A 63-year-old Japanese man was admitted to the hospital presenting with dyspnea. Echocardiography revealed marked left ventricular hypertrophy and diffuse myocardial thickening with pericardial effusion. The patient died of heart failure. An autopsy revealed that the whole pancreas, weighing 400 g, was occupied by tumor cells with neuroendocrine differentiation. The heart, weighing 780 g, showed numerous metastatic nodules and diffuse myocardial thickening. Histopathologically, the tumor was diagnosed as non-functioning pancreatic neuroendocrine carcinoma. Immunohistochemical analysis for D2-40 disclosed severe lymphatic infiltration of tumor cells, characterized by diffuse thickening of the myocardium.
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spelling pubmed-28039242010-01-10 Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report Kondo, Takeshi Kitazawa, Riko Kawata, Emiko Mori, Kiyoshi Kitazawa, Sohei Cases J Case Report We describe an autopsy case of non-functioning pancreatic neuroendocrine carcinoma metastasizing to the myocardium. A 63-year-old Japanese man was admitted to the hospital presenting with dyspnea. Echocardiography revealed marked left ventricular hypertrophy and diffuse myocardial thickening with pericardial effusion. The patient died of heart failure. An autopsy revealed that the whole pancreas, weighing 400 g, was occupied by tumor cells with neuroendocrine differentiation. The heart, weighing 780 g, showed numerous metastatic nodules and diffuse myocardial thickening. Histopathologically, the tumor was diagnosed as non-functioning pancreatic neuroendocrine carcinoma. Immunohistochemical analysis for D2-40 disclosed severe lymphatic infiltration of tumor cells, characterized by diffuse thickening of the myocardium. BioMed Central 2009-12-02 /pmc/articles/PMC2803924/ /pubmed/20062644 http://dx.doi.org/10.1186/1757-1626-2-9127 Text en Copyright ©2009 Kondo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kondo, Takeshi
Kitazawa, Riko
Kawata, Emiko
Mori, Kiyoshi
Kitazawa, Sohei
Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report
title Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report
title_full Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report
title_fullStr Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report
title_full_unstemmed Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report
title_short Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report
title_sort diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803924/
https://www.ncbi.nlm.nih.gov/pubmed/20062644
http://dx.doi.org/10.1186/1757-1626-2-9127
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AT kawataemiko diffusecardiaclymphaticinvolvementbymetastaticneuroendocrinecarcinomamimickinghypertrophiccardiomyopathyacasereport
AT morikiyoshi diffusecardiaclymphaticinvolvementbymetastaticneuroendocrinecarcinomamimickinghypertrophiccardiomyopathyacasereport
AT kitazawasohei diffusecardiaclymphaticinvolvementbymetastaticneuroendocrinecarcinomamimickinghypertrophiccardiomyopathyacasereport

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