Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70...

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Detalles Bibliográficos
Autores principales: Beauchamp, Marie-Claude, Yasmeen, Amber, Knafo, Ariane, Gotlieb, Walter H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804114/
https://www.ncbi.nlm.nih.gov/pubmed/20069126
http://dx.doi.org/10.1155/2010/257058
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author Beauchamp, Marie-Claude
Yasmeen, Amber
Knafo, Ariane
Gotlieb, Walter H.
author_facet Beauchamp, Marie-Claude
Yasmeen, Amber
Knafo, Ariane
Gotlieb, Walter H.
author_sort Beauchamp, Marie-Claude
collection PubMed
description Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70% of them will suffer a recurrence. Therefore, new therapeutic modalities are urgently needed to overcome chemoresistance observed in ovarian cancer patients. Evidence accumulates suggesting that the insulin/insulin growth factor (IGF) pathways could act as a good therapeutic target in several cancers, including ovarian cancer. In this paper, we will focus on the role of insulin/IGF in ovarian cancer tumorigenesis and treatment.
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spelling pubmed-28041142010-01-12 Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer Beauchamp, Marie-Claude Yasmeen, Amber Knafo, Ariane Gotlieb, Walter H. J Oncol Review Article Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70% of them will suffer a recurrence. Therefore, new therapeutic modalities are urgently needed to overcome chemoresistance observed in ovarian cancer patients. Evidence accumulates suggesting that the insulin/insulin growth factor (IGF) pathways could act as a good therapeutic target in several cancers, including ovarian cancer. In this paper, we will focus on the role of insulin/IGF in ovarian cancer tumorigenesis and treatment. Hindawi Publishing Corporation 2010 2010-01-05 /pmc/articles/PMC2804114/ /pubmed/20069126 http://dx.doi.org/10.1155/2010/257058 Text en Copyright © 2010 Marie-Claude Beauchamp et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Beauchamp, Marie-Claude
Yasmeen, Amber
Knafo, Ariane
Gotlieb, Walter H.
Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
title Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
title_full Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
title_fullStr Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
title_full_unstemmed Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
title_short Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
title_sort targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804114/
https://www.ncbi.nlm.nih.gov/pubmed/20069126
http://dx.doi.org/10.1155/2010/257058
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