Promoter architecture and the evolvability of gene expression

Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Her...

Descripción completa

Detalles Bibliográficos
Autores principales: Tirosh, Itay, Barkai, Naama, Verstrepen, Kevin J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804285/
https://www.ncbi.nlm.nih.gov/pubmed/20017897
http://dx.doi.org/10.1186/jbiol204
_version_ 1782176149966684160
author Tirosh, Itay
Barkai, Naama
Verstrepen, Kevin J
author_facet Tirosh, Itay
Barkai, Naama
Verstrepen, Kevin J
author_sort Tirosh, Itay
collection PubMed
description Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.
format Text
id pubmed-2804285
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-28042852010-06-14 Promoter architecture and the evolvability of gene expression Tirosh, Itay Barkai, Naama Verstrepen, Kevin J J Biol Opinion Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression. BioMed Central 2009 2009-12-14 /pmc/articles/PMC2804285/ /pubmed/20017897 http://dx.doi.org/10.1186/jbiol204 Text en Copyright ©2009 BioMed Central Ltd
spellingShingle Opinion
Tirosh, Itay
Barkai, Naama
Verstrepen, Kevin J
Promoter architecture and the evolvability of gene expression
title Promoter architecture and the evolvability of gene expression
title_full Promoter architecture and the evolvability of gene expression
title_fullStr Promoter architecture and the evolvability of gene expression
title_full_unstemmed Promoter architecture and the evolvability of gene expression
title_short Promoter architecture and the evolvability of gene expression
title_sort promoter architecture and the evolvability of gene expression
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804285/
https://www.ncbi.nlm.nih.gov/pubmed/20017897
http://dx.doi.org/10.1186/jbiol204
work_keys_str_mv AT tiroshitay promoterarchitectureandtheevolvabilityofgeneexpression
AT barkainaama promoterarchitectureandtheevolvabilityofgeneexpression
AT verstrepenkevinj promoterarchitectureandtheevolvabilityofgeneexpression

Ejemplares similares