Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?

The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can lar...

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Detalles Bibliográficos
Autores principales: Hughes, Amanda, Rando, Oliver J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804288/
https://www.ncbi.nlm.nih.gov/pubmed/20067596
http://dx.doi.org/10.1186/jbiol207
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author Hughes, Amanda
Rando, Oliver J
author_facet Hughes, Amanda
Rando, Oliver J
author_sort Hughes, Amanda
collection PubMed
description The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442
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spelling pubmed-28042882010-06-23 Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC? Hughes, Amanda Rando, Oliver J J Biol Minireview The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442 BioMed Central 2009 2009-12-23 /pmc/articles/PMC2804288/ /pubmed/20067596 http://dx.doi.org/10.1186/jbiol207 Text en Copyright ©2009 BioMed Central Ltd.
spellingShingle Minireview
Hughes, Amanda
Rando, Oliver J
Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
title Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
title_full Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
title_fullStr Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
title_full_unstemmed Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
title_short Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
title_sort chromatin 'programming' by sequence - is there more to the nucleosome code than %gc?
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804288/
https://www.ncbi.nlm.nih.gov/pubmed/20067596
http://dx.doi.org/10.1186/jbiol207
work_keys_str_mv AT hughesamanda chromatinprogrammingbysequenceistheremoretothenucleosomecodethangc
AT randooliverj chromatinprogrammingbysequenceistheremoretothenucleosomecodethangc

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