Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management

BACKGROUND: Lynch syndrome (LS) is associated with a high risk for colorectal cancer (CRC) and extracolonic malignancies, such as endometrial carcinoma (EC). The risk is dependent of the affected mismatch repair gene. The aim of the present study was to calculate the cumulative risk of LS related ca...

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Detalles Bibliográficos
Autores principales: Ramsoekh, Dewkoemar, Wagner, Anja, van Leerdam, Monique E, Dooijes, Dennis, Tops, Carli MJ, Steyerberg, Ewout W, Kuipers, Ernst J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804564/
https://www.ncbi.nlm.nih.gov/pubmed/20028567
http://dx.doi.org/10.1186/1897-4287-7-17

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