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Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)

BACKGROUND: Lipids, particularly low-density (LDL) and high-density (HDL) lipoproteins, are associated with increased risk of stroke and cardiovascular disease, probably due to atherosclerosis. The objective of this cross-sectional analysis was to investigate the relation between blood lipids and ca...

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Autores principales: Gardener, Hannah, Morte, David Della, Elkind, Mitchell SV, Sacco, Ralph L, Rundek, Tatjana
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804671/
https://www.ncbi.nlm.nih.gov/pubmed/20028534
http://dx.doi.org/10.1186/1471-2261-9-55
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author Gardener, Hannah
Morte, David Della
Elkind, Mitchell SV
Sacco, Ralph L
Rundek, Tatjana
author_facet Gardener, Hannah
Morte, David Della
Elkind, Mitchell SV
Sacco, Ralph L
Rundek, Tatjana
author_sort Gardener, Hannah
collection PubMed
description BACKGROUND: Lipids, particularly low-density (LDL) and high-density (HDL) lipoproteins, are associated with increased risk of stroke and cardiovascular disease, probably due to atherosclerosis. The objective of this cross-sectional analysis was to investigate the relation between blood lipids and carotid plaque. METHODS: As part of a prospective population-based study to determine the incidence and risk factors of stroke in a multiethnic population, we evaluated 1804 participants with lipid measurements and B-mode ultrasound of carotid arteries (mean age 69 +/- 10 years; 40% men; 51% Hispanic, 26% black, 23% white). The association between lipid parameters and carotid plaque was analyzed by multiple logistic regression. RESULTS: Plaque was present in 61% of participants. Mean total cholesterol was 202 +/- 41 mg/dl. After controlling for other lipid parameters, demographics, and risk factors, the only cholesterol subfraction associated with carotid plaque was LDL (OR per standard deviation (SD) = 1.14, 95% CI 1.02-1.27). Neither HDL nor triglycerides independently predicted carotid plaque. Apolipoprotein B (ApoB) was also associated with risk of plaque (OR per SD = 1.29, 95% CI 1.03-1.60). Apolipoprotein A-I (apoA-1) was associated with a decrease in multiple plaques (OR per SD = 0.76, 95% CI 0.60-0.97), while lipoprotein a was associated with an increased risk of multiple plaques (OR per SD = 1.31, 95% CI 1.03-1.66). ApoB:ApoA-I had the strongest relation with carotid plaque (OR per SD = 1.35, 95% CI 1.08-1.69). CONCLUSIONS: Among the common lipid parameters, LDL has the strongest relation with carotid plaque. Other lipid precursor proteins such as ApoB and ApoA-I may be stronger predictors of subclinical atherosclerosis, however, and better targets for treatment to reduce plaque formation and risk of cerebrovascular disease.
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spelling pubmed-28046712010-01-12 Lipids and carotid plaque in the Northern Manhattan Study (NOMAS) Gardener, Hannah Morte, David Della Elkind, Mitchell SV Sacco, Ralph L Rundek, Tatjana BMC Cardiovasc Disord Research article BACKGROUND: Lipids, particularly low-density (LDL) and high-density (HDL) lipoproteins, are associated with increased risk of stroke and cardiovascular disease, probably due to atherosclerosis. The objective of this cross-sectional analysis was to investigate the relation between blood lipids and carotid plaque. METHODS: As part of a prospective population-based study to determine the incidence and risk factors of stroke in a multiethnic population, we evaluated 1804 participants with lipid measurements and B-mode ultrasound of carotid arteries (mean age 69 +/- 10 years; 40% men; 51% Hispanic, 26% black, 23% white). The association between lipid parameters and carotid plaque was analyzed by multiple logistic regression. RESULTS: Plaque was present in 61% of participants. Mean total cholesterol was 202 +/- 41 mg/dl. After controlling for other lipid parameters, demographics, and risk factors, the only cholesterol subfraction associated with carotid plaque was LDL (OR per standard deviation (SD) = 1.14, 95% CI 1.02-1.27). Neither HDL nor triglycerides independently predicted carotid plaque. Apolipoprotein B (ApoB) was also associated with risk of plaque (OR per SD = 1.29, 95% CI 1.03-1.60). Apolipoprotein A-I (apoA-1) was associated with a decrease in multiple plaques (OR per SD = 0.76, 95% CI 0.60-0.97), while lipoprotein a was associated with an increased risk of multiple plaques (OR per SD = 1.31, 95% CI 1.03-1.66). ApoB:ApoA-I had the strongest relation with carotid plaque (OR per SD = 1.35, 95% CI 1.08-1.69). CONCLUSIONS: Among the common lipid parameters, LDL has the strongest relation with carotid plaque. Other lipid precursor proteins such as ApoB and ApoA-I may be stronger predictors of subclinical atherosclerosis, however, and better targets for treatment to reduce plaque formation and risk of cerebrovascular disease. BioMed Central 2009-12-22 /pmc/articles/PMC2804671/ /pubmed/20028534 http://dx.doi.org/10.1186/1471-2261-9-55 Text en Copyright ©2009 Gardener et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Gardener, Hannah
Morte, David Della
Elkind, Mitchell SV
Sacco, Ralph L
Rundek, Tatjana
Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
title Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
title_full Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
title_fullStr Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
title_full_unstemmed Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
title_short Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
title_sort lipids and carotid plaque in the northern manhattan study (nomas)
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804671/
https://www.ncbi.nlm.nih.gov/pubmed/20028534
http://dx.doi.org/10.1186/1471-2261-9-55
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