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Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem

BACKGROUND: Insecticide resistance in malaria vectors is a growing concern in many countries which requires immediate attention because of the limited chemical arsenal available for vector control. The current extent and distribution of this resistance in many parts of the continent is unknown and y...

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Autores principales: Ranson, Hilary, Abdallah, Hiba, Badolo, Athanase, Guelbeogo, Wamdaogo Moussa, Kerah-Hinzoumbé, Clément, Yangalbé-Kalnoné, Elise, Sagnon, N'Falé, Simard, Frédéric, Coetzee, Maureen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804687/
https://www.ncbi.nlm.nih.gov/pubmed/20015411
http://dx.doi.org/10.1186/1475-2875-8-299
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author Ranson, Hilary
Abdallah, Hiba
Badolo, Athanase
Guelbeogo, Wamdaogo Moussa
Kerah-Hinzoumbé, Clément
Yangalbé-Kalnoné, Elise
Sagnon, N'Falé
Simard, Frédéric
Coetzee, Maureen
author_facet Ranson, Hilary
Abdallah, Hiba
Badolo, Athanase
Guelbeogo, Wamdaogo Moussa
Kerah-Hinzoumbé, Clément
Yangalbé-Kalnoné, Elise
Sagnon, N'Falé
Simard, Frédéric
Coetzee, Maureen
author_sort Ranson, Hilary
collection PubMed
description BACKGROUND: Insecticide resistance in malaria vectors is a growing concern in many countries which requires immediate attention because of the limited chemical arsenal available for vector control. The current extent and distribution of this resistance in many parts of the continent is unknown and yet such information is essential for the planning of effective malaria control interventions. METHODS: In 2008, a network was established, with financial support from WHO/TDR, to investigate the extent of insecticide resistance in malaria vectors in five African countries. Here, the results of bioassays on Anopheles gambiae sensu lato from two rounds of monitoring from 12 sentinel sites in three of the partner countries are reported. RESULTS: Resistance is very heterogeneous even over relatively small distances. Furthermore, in some sites, large differences in mortality rates were observed during the course of the malaria transmission season. Using WHO diagnostic doses, all populations from Burkina Faso and Chad and two of the four populations from Sudan were classified as resistant to permethrin and/or deltamethrin. Very high frequencies of DDT resistance were found in urban areas in Burkina Faso and Sudan and in a cotton-growing district in Chad. In areas where both An. gambiae s.s. and Anopheles arabiensis were present, resistance was found in both species, although generally at a higher frequency in An gambiae s.s. Anopheles gambiae s.l. remains largely susceptible to the organophosphate fenitrothion and the carbamate bendiocarb in the majority of the sentinel sites with the exception of two sites in Burkina Faso. In the cotton-growing region of Soumousso in Burkina Faso, the vector population is resistant to all four classes of insecticide available for malaria control. CONCLUSIONS: Possible factors influencing the frequency of resistant individuals observed in the sentinel sites are discussed. The results of this study highlight the importance of standardized longitudinal insecticide resistance monitoring and the urgent need for studies to monitor the impact of this resistance on malaria vector control activities.
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spelling pubmed-28046872010-01-12 Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem Ranson, Hilary Abdallah, Hiba Badolo, Athanase Guelbeogo, Wamdaogo Moussa Kerah-Hinzoumbé, Clément Yangalbé-Kalnoné, Elise Sagnon, N'Falé Simard, Frédéric Coetzee, Maureen Malar J Research BACKGROUND: Insecticide resistance in malaria vectors is a growing concern in many countries which requires immediate attention because of the limited chemical arsenal available for vector control. The current extent and distribution of this resistance in many parts of the continent is unknown and yet such information is essential for the planning of effective malaria control interventions. METHODS: In 2008, a network was established, with financial support from WHO/TDR, to investigate the extent of insecticide resistance in malaria vectors in five African countries. Here, the results of bioassays on Anopheles gambiae sensu lato from two rounds of monitoring from 12 sentinel sites in three of the partner countries are reported. RESULTS: Resistance is very heterogeneous even over relatively small distances. Furthermore, in some sites, large differences in mortality rates were observed during the course of the malaria transmission season. Using WHO diagnostic doses, all populations from Burkina Faso and Chad and two of the four populations from Sudan were classified as resistant to permethrin and/or deltamethrin. Very high frequencies of DDT resistance were found in urban areas in Burkina Faso and Sudan and in a cotton-growing district in Chad. In areas where both An. gambiae s.s. and Anopheles arabiensis were present, resistance was found in both species, although generally at a higher frequency in An gambiae s.s. Anopheles gambiae s.l. remains largely susceptible to the organophosphate fenitrothion and the carbamate bendiocarb in the majority of the sentinel sites with the exception of two sites in Burkina Faso. In the cotton-growing region of Soumousso in Burkina Faso, the vector population is resistant to all four classes of insecticide available for malaria control. CONCLUSIONS: Possible factors influencing the frequency of resistant individuals observed in the sentinel sites are discussed. The results of this study highlight the importance of standardized longitudinal insecticide resistance monitoring and the urgent need for studies to monitor the impact of this resistance on malaria vector control activities. BioMed Central 2009-12-17 /pmc/articles/PMC2804687/ /pubmed/20015411 http://dx.doi.org/10.1186/1475-2875-8-299 Text en Copyright ©2009 Ranson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ranson, Hilary
Abdallah, Hiba
Badolo, Athanase
Guelbeogo, Wamdaogo Moussa
Kerah-Hinzoumbé, Clément
Yangalbé-Kalnoné, Elise
Sagnon, N'Falé
Simard, Frédéric
Coetzee, Maureen
Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
title Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
title_full Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
title_fullStr Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
title_full_unstemmed Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
title_short Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
title_sort insecticide resistance in anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804687/
https://www.ncbi.nlm.nih.gov/pubmed/20015411
http://dx.doi.org/10.1186/1475-2875-8-299
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