Social phobia following maprotiline: the first case report

INTRODUCTION: It has long been recognized that anxiety symptoms and syndromes may be caused by medication and/or substance of abuse. The aim of this report is to present a patient who experienced social phobia following maprotiline, an adverse drug reaction which has not been reported previously with this agent. CASE PRESENTATION: A 27 year-old male patient was suffering from dysthymia for 6 years. He received different kinds of pharmacotherapy including TCAs, SSRIs, MAOIs. Due to his poor response, augmenting therapy with liothyronine and lithium and also cognitive therapy have been tried for him. Since he did not respond well to these treatments, maprotiline was administered for him 50 mg daily. His psychological problems improved with maprotiline, however he experienced social phobia that has not experienced yet. CONCLUSION: This could underlie the precipitation of social phobia after maprotiline. However there is a need for further studies.