Protein Modifications as Potential Biomarkers in Breast Cancer

A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying...

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Detalles Bibliográficos
Autores principales: Jin, Hongjun, Zangar, Richard C.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805424/
https://www.ncbi.nlm.nih.gov/pubmed/20072669
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author Jin, Hongjun
Zangar, Richard C.
author_facet Jin, Hongjun
Zangar, Richard C.
author_sort Jin, Hongjun
collection PubMed
description A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.
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spelling pubmed-28054242010-01-13 Protein Modifications as Potential Biomarkers in Breast Cancer Jin, Hongjun Zangar, Richard C. Biomark Insights Review A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs. Libertas Academica 2009-11-30 /pmc/articles/PMC2805424/ /pubmed/20072669 Text en © 2009 The authors. http://creativecommons.org/licenses/by/2.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/2.0/).
spellingShingle Review
Jin, Hongjun
Zangar, Richard C.
Protein Modifications as Potential Biomarkers in Breast Cancer
title Protein Modifications as Potential Biomarkers in Breast Cancer
title_full Protein Modifications as Potential Biomarkers in Breast Cancer
title_fullStr Protein Modifications as Potential Biomarkers in Breast Cancer
title_full_unstemmed Protein Modifications as Potential Biomarkers in Breast Cancer
title_short Protein Modifications as Potential Biomarkers in Breast Cancer
title_sort protein modifications as potential biomarkers in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805424/
https://www.ncbi.nlm.nih.gov/pubmed/20072669
work_keys_str_mv AT jinhongjun proteinmodificationsaspotentialbiomarkersinbreastcancer
AT zangarrichardc proteinmodificationsaspotentialbiomarkersinbreastcancer

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