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Defining Hematopoietic Stem and Progenitor Cell Turnover by Analysis of Histone 2B-GFP Dilution

Hematopoietic stem cells (HSCs) are thought to divide infrequently based on their resistance to cytotoxic injury targeted at rapidly cycling cells1, 2 and have been presumed to retain labels such as the nucleotide analogue 5-bromodeoxyuridine (BrdU). However, recently it has been demonstrated that B...

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Detalles Bibliográficos
Autores principales: Foudi, Adlen, Hochedlinger, Konrad, Van Buren, Denille, Schindler, Jeffrey W., Jaenisch, Rudolf, Carey, Vincent, Hock, Hanno
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805441/
https://www.ncbi.nlm.nih.gov/pubmed/19060879
http://dx.doi.org/10.1038/nbt.1517