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Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards
BACKGROUND: Airway inflammation and airway hyperresponsiveness (AHR) are two characteristic features of asthma. Fractional exhaled nitric oxide (FENO) has shown good correlation with AHR in asthmatics. Less information is available about FENO as a marker of inflammation from work exposures. We thus...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805603/ https://www.ncbi.nlm.nih.gov/pubmed/20043846 http://dx.doi.org/10.1186/1471-2466-9-53 |
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author | Demange, Valérie Bohadana, Abraham Massin, Nicole Wild, Pascal |
author_facet | Demange, Valérie Bohadana, Abraham Massin, Nicole Wild, Pascal |
author_sort | Demange, Valérie |
collection | PubMed |
description | BACKGROUND: Airway inflammation and airway hyperresponsiveness (AHR) are two characteristic features of asthma. Fractional exhaled nitric oxide (FENO) has shown good correlation with AHR in asthmatics. Less information is available about FENO as a marker of inflammation from work exposures. We thus examined the relation between FENO and AHR in lifeguards undergoing exposure to chloramines in indoor pools. METHODS: 39 lifeguards at six indoor pools were given a respiratory health questionnaire, FENO measurements, spirometry, and a methacholine bronchial challenge (MBC) test. Subjects were labeled MBC+ if the forced expiratory volume (FEV1) fell by 20% or more. The normalized linear dose-response slope (NDRS) was calculated as the percentage fall in FEV1 at the last dose divided by the total dose given. The relation between MBC and FENO was assessed using logistic regression adjusting on confounding factors. The association between NDRS and log-transformed values of FENO was tested in a multiple linear regression model. RESULTS: The prevalence of lifeguards MBC+ was 37.5%. In reactors, the median FENO was 18.9 ppb (90% of the predicted value) vs. 12.5 ppb (73% predicted) in non-reactors. FENO values ≥ 60% of predicted values were 80% sensitive and 42% specific to identify subjects MBC+. In the logistic regression model no other factor had an effect on MBC after adjusting for FENO. In the linear regression model, NDRS was significantly predicted by log FENO. CONCLUSIONS: In lifeguards working in indoor swimming pools, elevated FENO levels are associated with increased airway responsiveness. |
format | Text |
id | pubmed-2805603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28056032010-01-13 Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards Demange, Valérie Bohadana, Abraham Massin, Nicole Wild, Pascal BMC Pulm Med Research article BACKGROUND: Airway inflammation and airway hyperresponsiveness (AHR) are two characteristic features of asthma. Fractional exhaled nitric oxide (FENO) has shown good correlation with AHR in asthmatics. Less information is available about FENO as a marker of inflammation from work exposures. We thus examined the relation between FENO and AHR in lifeguards undergoing exposure to chloramines in indoor pools. METHODS: 39 lifeguards at six indoor pools were given a respiratory health questionnaire, FENO measurements, spirometry, and a methacholine bronchial challenge (MBC) test. Subjects were labeled MBC+ if the forced expiratory volume (FEV1) fell by 20% or more. The normalized linear dose-response slope (NDRS) was calculated as the percentage fall in FEV1 at the last dose divided by the total dose given. The relation between MBC and FENO was assessed using logistic regression adjusting on confounding factors. The association between NDRS and log-transformed values of FENO was tested in a multiple linear regression model. RESULTS: The prevalence of lifeguards MBC+ was 37.5%. In reactors, the median FENO was 18.9 ppb (90% of the predicted value) vs. 12.5 ppb (73% predicted) in non-reactors. FENO values ≥ 60% of predicted values were 80% sensitive and 42% specific to identify subjects MBC+. In the logistic regression model no other factor had an effect on MBC after adjusting for FENO. In the linear regression model, NDRS was significantly predicted by log FENO. CONCLUSIONS: In lifeguards working in indoor swimming pools, elevated FENO levels are associated with increased airway responsiveness. BioMed Central 2009-12-31 /pmc/articles/PMC2805603/ /pubmed/20043846 http://dx.doi.org/10.1186/1471-2466-9-53 Text en Copyright ©2009 Demange et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research article Demange, Valérie Bohadana, Abraham Massin, Nicole Wild, Pascal Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards |
title | Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards |
title_full | Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards |
title_fullStr | Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards |
title_full_unstemmed | Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards |
title_short | Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards |
title_sort | exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805603/ https://www.ncbi.nlm.nih.gov/pubmed/20043846 http://dx.doi.org/10.1186/1471-2466-9-53 |
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