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Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents
OBJECTIVES: This study aimed to determine the prevalence of the metabolic syndrome, abnormalities of liver enzymes and sonographic fatty liver, as well as the inter-related associations in normal weight, overweight and obese children and adolescents. METHODS: This cross-sectional study was conducted...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805605/ https://www.ncbi.nlm.nih.gov/pubmed/20028551 http://dx.doi.org/10.1186/1758-5996-1-29 |
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author | Kelishadi, Roya Cook, Stephen R Adibi, Atoosa Faghihimani, Zahra Ghatrehsamani, Shohreh Beihaghi, Abolfazl Salehi, Hamidreza Khavarian, Noushin Poursafa, Parinaz |
author_facet | Kelishadi, Roya Cook, Stephen R Adibi, Atoosa Faghihimani, Zahra Ghatrehsamani, Shohreh Beihaghi, Abolfazl Salehi, Hamidreza Khavarian, Noushin Poursafa, Parinaz |
author_sort | Kelishadi, Roya |
collection | PubMed |
description | OBJECTIVES: This study aimed to determine the prevalence of the metabolic syndrome, abnormalities of liver enzymes and sonographic fatty liver, as well as the inter-related associations in normal weight, overweight and obese children and adolescents. METHODS: This cross-sectional study was conducted among a sample of 1107 students (56.1% girls), aged 6-18 years in Isfahan, Iran. In addition to physical examination, fasting blood glucose, serum lipid profile and liver enzymes were determined. Liver sonography was performed among 931 participants. These variables were compared among participants with different body mass index (BMI) categories. RESULTS: From lower to higher BMI category, alanine aminotransferase (ALT), total cholesterol, LDL-cholesterol, triglycerides and systolic blood pressure increased, and HDL-cholesterol decreased significantly. Elevated ALT, aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were documented in respectively 4.1%, 6.6% and 9.8% of normal weight group. The corresponding figure was 9.5%, 9.8% and 9.1% in overweight group, and 16.9%, 14.9% and 10.8% in obese group, respectively. In all BMI categories, ALT increased significantly by increasing the number of the components of the metabolic syndrome. Odds ratio for elevated liver enzymes and sonographic fatty liver increased significantly with higher number of the components of the metabolic syndrome and higher BMI categories before and after adjustment for age. CONCLUSIONS: Because of the interrelationship of biochemical and sonographic indexes of fatty liver with the components of the metabolic syndrome, and with increase in their number, it is suggested to determine the clinical impact of such association in future longitudinal studies. |
format | Text |
id | pubmed-2805605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28056052010-01-13 Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents Kelishadi, Roya Cook, Stephen R Adibi, Atoosa Faghihimani, Zahra Ghatrehsamani, Shohreh Beihaghi, Abolfazl Salehi, Hamidreza Khavarian, Noushin Poursafa, Parinaz Diabetol Metab Syndr Research OBJECTIVES: This study aimed to determine the prevalence of the metabolic syndrome, abnormalities of liver enzymes and sonographic fatty liver, as well as the inter-related associations in normal weight, overweight and obese children and adolescents. METHODS: This cross-sectional study was conducted among a sample of 1107 students (56.1% girls), aged 6-18 years in Isfahan, Iran. In addition to physical examination, fasting blood glucose, serum lipid profile and liver enzymes were determined. Liver sonography was performed among 931 participants. These variables were compared among participants with different body mass index (BMI) categories. RESULTS: From lower to higher BMI category, alanine aminotransferase (ALT), total cholesterol, LDL-cholesterol, triglycerides and systolic blood pressure increased, and HDL-cholesterol decreased significantly. Elevated ALT, aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were documented in respectively 4.1%, 6.6% and 9.8% of normal weight group. The corresponding figure was 9.5%, 9.8% and 9.1% in overweight group, and 16.9%, 14.9% and 10.8% in obese group, respectively. In all BMI categories, ALT increased significantly by increasing the number of the components of the metabolic syndrome. Odds ratio for elevated liver enzymes and sonographic fatty liver increased significantly with higher number of the components of the metabolic syndrome and higher BMI categories before and after adjustment for age. CONCLUSIONS: Because of the interrelationship of biochemical and sonographic indexes of fatty liver with the components of the metabolic syndrome, and with increase in their number, it is suggested to determine the clinical impact of such association in future longitudinal studies. BioMed Central 2009-12-22 /pmc/articles/PMC2805605/ /pubmed/20028551 http://dx.doi.org/10.1186/1758-5996-1-29 Text en Copyright ©2009 Kelishadi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Kelishadi, Roya Cook, Stephen R Adibi, Atoosa Faghihimani, Zahra Ghatrehsamani, Shohreh Beihaghi, Abolfazl Salehi, Hamidreza Khavarian, Noushin Poursafa, Parinaz Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents |
title | Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents |
title_full | Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents |
title_fullStr | Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents |
title_full_unstemmed | Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents |
title_short | Association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents |
title_sort | association of the components of the metabolic syndrome with non- alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805605/ https://www.ncbi.nlm.nih.gov/pubmed/20028551 http://dx.doi.org/10.1186/1758-5996-1-29 |
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