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Role of ADAM and ADAMTS metalloproteinases in airway diseases

Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related...

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Autores principales: Paulissen, Genevieve, Rocks, Natacha, Gueders, Maud M, Crahay, Celine, Quesada-Calvo, Florence, Bekaert, Sandrine, Hacha, Jonathan, El Hour, Mehdi, Foidart, Jean-Michel, Noel, Agnes, Cataldo, Didier D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805617/
https://www.ncbi.nlm.nih.gov/pubmed/20034386
http://dx.doi.org/10.1186/1465-9921-10-127
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author Paulissen, Genevieve
Rocks, Natacha
Gueders, Maud M
Crahay, Celine
Quesada-Calvo, Florence
Bekaert, Sandrine
Hacha, Jonathan
El Hour, Mehdi
Foidart, Jean-Michel
Noel, Agnes
Cataldo, Didier D
author_facet Paulissen, Genevieve
Rocks, Natacha
Gueders, Maud M
Crahay, Celine
Quesada-Calvo, Florence
Bekaert, Sandrine
Hacha, Jonathan
El Hour, Mehdi
Foidart, Jean-Michel
Noel, Agnes
Cataldo, Didier D
author_sort Paulissen, Genevieve
collection PubMed
description Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related to Matrix Metalloproteinases (MMPs). These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules. Proteinases of the ADAM family are associated to various physiological and pathological processes and display a wide spectrum of biological effects encompassing cell fusion, cell adhesion, "shedding process", cleavage of various substrates from the extracellular matrix, growth factors or cytokines... This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD.
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spelling pubmed-28056172010-01-13 Role of ADAM and ADAMTS metalloproteinases in airway diseases Paulissen, Genevieve Rocks, Natacha Gueders, Maud M Crahay, Celine Quesada-Calvo, Florence Bekaert, Sandrine Hacha, Jonathan El Hour, Mehdi Foidart, Jean-Michel Noel, Agnes Cataldo, Didier D Respir Res Review Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related to Matrix Metalloproteinases (MMPs). These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules. Proteinases of the ADAM family are associated to various physiological and pathological processes and display a wide spectrum of biological effects encompassing cell fusion, cell adhesion, "shedding process", cleavage of various substrates from the extracellular matrix, growth factors or cytokines... This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD. BioMed Central 2009 2009-12-24 /pmc/articles/PMC2805617/ /pubmed/20034386 http://dx.doi.org/10.1186/1465-9921-10-127 Text en Copyright ©2009 Paulissen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Paulissen, Genevieve
Rocks, Natacha
Gueders, Maud M
Crahay, Celine
Quesada-Calvo, Florence
Bekaert, Sandrine
Hacha, Jonathan
El Hour, Mehdi
Foidart, Jean-Michel
Noel, Agnes
Cataldo, Didier D
Role of ADAM and ADAMTS metalloproteinases in airway diseases
title Role of ADAM and ADAMTS metalloproteinases in airway diseases
title_full Role of ADAM and ADAMTS metalloproteinases in airway diseases
title_fullStr Role of ADAM and ADAMTS metalloproteinases in airway diseases
title_full_unstemmed Role of ADAM and ADAMTS metalloproteinases in airway diseases
title_short Role of ADAM and ADAMTS metalloproteinases in airway diseases
title_sort role of adam and adamts metalloproteinases in airway diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805617/
https://www.ncbi.nlm.nih.gov/pubmed/20034386
http://dx.doi.org/10.1186/1465-9921-10-127
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