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Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination

OBJECTIVE: To study the neurocognitive profile and its relationship to prefrontal dysfunction in non-demented Parkinson's disease (PD) with deficient haptic perception. METHODS: Twelve right-handed patients with PD and 12 healthy control subjects underwent thorough neuropsychological testing in...

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Autores principales: Bohlhalter, Stephan, Abela, Eugenio, Weniger, Dorothea, Weder, Bruno
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805678/
https://www.ncbi.nlm.nih.gov/pubmed/20003499
http://dx.doi.org/10.1186/1744-9081-5-49
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author Bohlhalter, Stephan
Abela, Eugenio
Weniger, Dorothea
Weder, Bruno
author_facet Bohlhalter, Stephan
Abela, Eugenio
Weniger, Dorothea
Weder, Bruno
author_sort Bohlhalter, Stephan
collection PubMed
description OBJECTIVE: To study the neurocognitive profile and its relationship to prefrontal dysfunction in non-demented Parkinson's disease (PD) with deficient haptic perception. METHODS: Twelve right-handed patients with PD and 12 healthy control subjects underwent thorough neuropsychological testing including Rey complex figure, Rey auditory verbal and figural learning test, figural and verbal fluency, and Stroop test. Test scores reflecting significant differences between patients and healthy subjects were correlated with the individual expression coefficients of one principal component, obtained in a principal component analysis of an oxygen-15-labeled water PET study exploring somatosensory discrimination that differentiated between the two groups and involved prefrontal cortices. RESULTS: We found significantly decreased total scores for the verbal learning trials and verbal delayed free recall in PD patients compared with normal volunteers. Further analysis of these parameters using Spearman's ranking correlation showed a significantly negative correlation of deficient verbal recall with expression coefficients of the principal component whose image showed a subcortical-cortical network, including right dorsolateral-prefrontal cortex, in PD patients. CONCLUSION: PD patients with disrupted right dorsolateral prefrontal cortex function and associated diminished somatosensory discrimination are impaired also in verbal memory functions. A negative correlation between delayed verbal free recall and PET activation in a network including the prefrontal cortices suggests that verbal cues and accordingly declarative memory processes may be operative in PD during activities that demand sustained attention such as somatosensory discrimination. Verbal cues may be compensatory in nature and help to non-specifically enhance focused attention in the presence of a functionally disrupted prefrontal cortex.
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spelling pubmed-28056782010-01-13 Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination Bohlhalter, Stephan Abela, Eugenio Weniger, Dorothea Weder, Bruno Behav Brain Funct Research OBJECTIVE: To study the neurocognitive profile and its relationship to prefrontal dysfunction in non-demented Parkinson's disease (PD) with deficient haptic perception. METHODS: Twelve right-handed patients with PD and 12 healthy control subjects underwent thorough neuropsychological testing including Rey complex figure, Rey auditory verbal and figural learning test, figural and verbal fluency, and Stroop test. Test scores reflecting significant differences between patients and healthy subjects were correlated with the individual expression coefficients of one principal component, obtained in a principal component analysis of an oxygen-15-labeled water PET study exploring somatosensory discrimination that differentiated between the two groups and involved prefrontal cortices. RESULTS: We found significantly decreased total scores for the verbal learning trials and verbal delayed free recall in PD patients compared with normal volunteers. Further analysis of these parameters using Spearman's ranking correlation showed a significantly negative correlation of deficient verbal recall with expression coefficients of the principal component whose image showed a subcortical-cortical network, including right dorsolateral-prefrontal cortex, in PD patients. CONCLUSION: PD patients with disrupted right dorsolateral prefrontal cortex function and associated diminished somatosensory discrimination are impaired also in verbal memory functions. A negative correlation between delayed verbal free recall and PET activation in a network including the prefrontal cortices suggests that verbal cues and accordingly declarative memory processes may be operative in PD during activities that demand sustained attention such as somatosensory discrimination. Verbal cues may be compensatory in nature and help to non-specifically enhance focused attention in the presence of a functionally disrupted prefrontal cortex. BioMed Central 2009-12-15 /pmc/articles/PMC2805678/ /pubmed/20003499 http://dx.doi.org/10.1186/1744-9081-5-49 Text en Copyright ©2009 Bohlhalter et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Bohlhalter, Stephan
Abela, Eugenio
Weniger, Dorothea
Weder, Bruno
Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
title Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
title_full Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
title_fullStr Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
title_full_unstemmed Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
title_short Impaired verbal memory in Parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
title_sort impaired verbal memory in parkinson disease: relationship to prefrontal dysfunction and somatosensory discrimination
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805678/
https://www.ncbi.nlm.nih.gov/pubmed/20003499
http://dx.doi.org/10.1186/1744-9081-5-49
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