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Ontogeny of midazolam glucuronidation in preterm infants

PURPOSE: In preterm infants, the biotransformation of midazolam (M) to 1-OH-midazolam (OHM) by cytochrome P450 3A4 (CYP3A4) is developmentally immature, but it is currently unknown whether the glucuronidation of OHM to 1-OH-midazolam glucuronide (OHMG) is also decreased. The aim of our study was to...

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Detalles Bibliográficos
Autores principales:	de Wildt, Saskia N., Kearns, Greg L., Murry, Darryl J., Koren, Gideon, van den Anker, John N.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2009
Materias:	Pharmacokinetics and Disposition
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805794/ https://www.ncbi.nlm.nih.gov/pubmed/19838691 http://dx.doi.org/10.1007/s00228-009-0741-5

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