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Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?

Since the inception of global gene expression profiling platforms in the mid‐1990s, there has been a significant increase in publications of differentially expressed genes in the process of epileptogenesis. In particular for mesial temporal lobe epilepsy, the presence of a latency period between the...

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Detalles Bibliográficos
Autores principales: Wang, Yi Yuen, Smith, Paul, Murphy, Michael, Cook, Mark
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805866/
https://www.ncbi.nlm.nih.gov/pubmed/19243383
http://dx.doi.org/10.1111/j.1750-3639.2008.00254.x
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author Wang, Yi Yuen
Smith, Paul
Murphy, Michael
Cook, Mark
author_facet Wang, Yi Yuen
Smith, Paul
Murphy, Michael
Cook, Mark
author_sort Wang, Yi Yuen
collection PubMed
description Since the inception of global gene expression profiling platforms in the mid‐1990s, there has been a significant increase in publications of differentially expressed genes in the process of epileptogenesis. In particular for mesial temporal lobe epilepsy, the presence of a latency period between the first manifestation of seizures to chronic epilepsy provides the opportunity for therapeutic interventions at the molecular biology level. Using global expression profiling techniques, approximately 2000 genes have been published demonstrating differential expression in mesial temporal epilepsy. The majority of these changes, however, are specific to laboratory or experimental conditions with only 53 genes demonstrating changes in more than two publications. To this end, we review the current status of gene expression profiling in epileptogenesis and suggest standard guidelines to be followed for greater accuracy and reproducibility of results.
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spelling pubmed-28058662010-01-21 Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion? Wang, Yi Yuen Smith, Paul Murphy, Michael Cook, Mark Brain Pathol Review Articles Since the inception of global gene expression profiling platforms in the mid‐1990s, there has been a significant increase in publications of differentially expressed genes in the process of epileptogenesis. In particular for mesial temporal lobe epilepsy, the presence of a latency period between the first manifestation of seizures to chronic epilepsy provides the opportunity for therapeutic interventions at the molecular biology level. Using global expression profiling techniques, approximately 2000 genes have been published demonstrating differential expression in mesial temporal epilepsy. The majority of these changes, however, are specific to laboratory or experimental conditions with only 53 genes demonstrating changes in more than two publications. To this end, we review the current status of gene expression profiling in epileptogenesis and suggest standard guidelines to be followed for greater accuracy and reproducibility of results. Blackwell Publishing Ltd 2009-02-24 /pmc/articles/PMC2805866/ /pubmed/19243383 http://dx.doi.org/10.1111/j.1750-3639.2008.00254.x Text en © 2009 The Authors. Journal Compilation © 2009 International Society of Neuropathology Open access.
spellingShingle Review Articles
Wang, Yi Yuen
Smith, Paul
Murphy, Michael
Cook, Mark
Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?
title Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?
title_full Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?
title_fullStr Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?
title_full_unstemmed Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?
title_short Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion?
title_sort global expression profiling in epileptogenesis: does it add to the confusion?
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805866/
https://www.ncbi.nlm.nih.gov/pubmed/19243383
http://dx.doi.org/10.1111/j.1750-3639.2008.00254.x
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