A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

The caspase-3 zymogen has essentially zero activity until it is cleaved by initiator caspases during apoptosis. However, a mutation of V266E in the dimer interface activates the protease in the absence of chain cleavage. We show that low concentrations of the pseudo-activated procaspase-3 kill mamma...

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Detalles Bibliográficos
Autores principales: Walters, Jad, Pop, Cristina, Scott, Fiona L., Drag, Marcin, Swartz, Paul, Mattos, Carla, Salvesen, Guy S., Clark, A. Clay
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805924/
https://www.ncbi.nlm.nih.gov/pubmed/19788411
http://dx.doi.org/10.1042/BJ20090825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805924/
https://www.ncbi.nlm.nih.gov/pubmed/19788411
http://dx.doi.org/10.1042/BJ20090825

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