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A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis
The caspase-3 zymogen has essentially zero activity until it is cleaved by initiator caspases during apoptosis. However, a mutation of V266E in the dimer interface activates the protease in the absence of chain cleavage. We show that low concentrations of the pseudo-activated procaspase-3 kill mamma...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805924/ https://www.ncbi.nlm.nih.gov/pubmed/19788411 http://dx.doi.org/10.1042/BJ20090825 |