Growth and aging: a common molecular mechanism

It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-rel...

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Detalles Bibliográficos
Autores principales: Blagosklonny, Mikhail V., Hall, Michael N.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806018/
https://www.ncbi.nlm.nih.gov/pubmed/20157523
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author Blagosklonny, Mikhail V.
Hall, Michael N.
author_facet Blagosklonny, Mikhail V.
Hall, Michael N.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
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spelling pubmed-28060182010-02-12 Growth and aging: a common molecular mechanism Blagosklonny, Mikhail V. Hall, Michael N. Aging (Albany NY) Review It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human. Impact Journals LLC 2009-04-20 /pmc/articles/PMC2806018/ /pubmed/20157523 Text en Copyright: ©2009 Blagosklonny et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Blagosklonny, Mikhail V.
Hall, Michael N.
Growth and aging: a common molecular mechanism
title Growth and aging: a common molecular mechanism
title_full Growth and aging: a common molecular mechanism
title_fullStr Growth and aging: a common molecular mechanism
title_full_unstemmed Growth and aging: a common molecular mechanism
title_short Growth and aging: a common molecular mechanism
title_sort growth and aging: a common molecular mechanism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806018/
https://www.ncbi.nlm.nih.gov/pubmed/20157523
work_keys_str_mv AT blagosklonnymikhailv growthandagingacommonmolecularmechanism
AT hallmichaeln growthandagingacommonmolecularmechanism

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