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Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1
Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of regeneration machinery to replace the damaged muscle. These pathological changes, known as muscle wasting, can be attributed to the activation of several prot...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806025/ https://www.ncbi.nlm.nih.gov/pubmed/20157530 |
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author | Scicchitano, Bianca Maria Rizzuto, Emanuele Musarò, Antonio |
author_facet | Scicchitano, Bianca Maria Rizzuto, Emanuele Musarò, Antonio |
author_sort | Scicchitano, Bianca Maria |
collection | PubMed |
description | Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of regeneration machinery to replace the damaged muscle. These pathological changes, known as muscle wasting, can be attributed to the activation of several proteolytic systems, such as calpain, ubiquitin-proteasome and caspases, and to the alteration in muscle growth factors. Among them, insulin-like growth factor-1 (IGF-1) has been implicated in the control of skeletal muscle growth, differentiation, survival, and regeneration and has been considered a promising therapeutic agent in staving off the advance of muscle weakness. Here we review the molecular basis of muscle wasting associated with diseases, such as sarcopenia, muscular dystrophy and Amyotrophic Lateral Sclerosis, and discuss the potential therapeutic role of local IGF-1 isoforms in muscle aging and diseases. |
format | Text |
id | pubmed-2806025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-28060252010-02-12 Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1 Scicchitano, Bianca Maria Rizzuto, Emanuele Musarò, Antonio Aging (Albany NY) Review Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of regeneration machinery to replace the damaged muscle. These pathological changes, known as muscle wasting, can be attributed to the activation of several proteolytic systems, such as calpain, ubiquitin-proteasome and caspases, and to the alteration in muscle growth factors. Among them, insulin-like growth factor-1 (IGF-1) has been implicated in the control of skeletal muscle growth, differentiation, survival, and regeneration and has been considered a promising therapeutic agent in staving off the advance of muscle weakness. Here we review the molecular basis of muscle wasting associated with diseases, such as sarcopenia, muscular dystrophy and Amyotrophic Lateral Sclerosis, and discuss the potential therapeutic role of local IGF-1 isoforms in muscle aging and diseases. Impact Journals LLC 2009-05-13 /pmc/articles/PMC2806025/ /pubmed/20157530 Text en Copyright: ©2009 Scicchitano et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Scicchitano, Bianca Maria Rizzuto, Emanuele Musarò, Antonio Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1 |
title | Counteracting muscle wasting in aging and neuromuscular diseases:
the critical role of IGF-1 |
title_full | Counteracting muscle wasting in aging and neuromuscular diseases:
the critical role of IGF-1 |
title_fullStr | Counteracting muscle wasting in aging and neuromuscular diseases:
the critical role of IGF-1 |
title_full_unstemmed | Counteracting muscle wasting in aging and neuromuscular diseases:
the critical role of IGF-1 |
title_short | Counteracting muscle wasting in aging and neuromuscular diseases:
the critical role of IGF-1 |
title_sort | counteracting muscle wasting in aging and neuromuscular diseases:
the critical role of igf-1 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806025/ https://www.ncbi.nlm.nih.gov/pubmed/20157530 |
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