mTOR's role in ageing: protein synthesis or autophagy?

The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such funct...

Descripción completa

Detalles Bibliográficos
Autores principales: Hands, Sarah L., Proud, Christopher G., Wyttenbach, Andreas
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806042/
https://www.ncbi.nlm.nih.gov/pubmed/20157541
_version_ 1782176253817651200
author Hands, Sarah L.
Proud, Christopher G.
Wyttenbach, Andreas
author_facet Hands, Sarah L.
Proud, Christopher G.
Wyttenbach, Andreas
author_sort Hands, Sarah L.
collection PubMed
description The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.
format Text
id pubmed-2806042
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-28060422010-02-12 mTOR's role in ageing: protein synthesis or autophagy? Hands, Sarah L. Proud, Christopher G. Wyttenbach, Andreas Aging (Albany NY) Review The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways. Impact Journals LLC 2009-07-20 /pmc/articles/PMC2806042/ /pubmed/20157541 Text en Copyright: ©2009 Hands et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Hands, Sarah L.
Proud, Christopher G.
Wyttenbach, Andreas
mTOR's role in ageing: protein synthesis or autophagy?
title mTOR's role in ageing: protein synthesis or autophagy?
title_full mTOR's role in ageing: protein synthesis or autophagy?
title_fullStr mTOR's role in ageing: protein synthesis or autophagy?
title_full_unstemmed mTOR's role in ageing: protein synthesis or autophagy?
title_short mTOR's role in ageing: protein synthesis or autophagy?
title_sort mtor's role in ageing: protein synthesis or autophagy?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806042/
https://www.ncbi.nlm.nih.gov/pubmed/20157541
work_keys_str_mv AT handssarahl mtorsroleinageingproteinsynthesisorautophagy
AT proudchristopherg mtorsroleinageingproteinsynthesisorautophagy
AT wyttenbachandreas mtorsroleinageingproteinsynthesisorautophagy

Ejemplares similares