Human insulin/IGF-1 and familial longevity at middle age

Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The ev...

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Detalles Bibliográficos
Autores principales: Rozing, Maarten P., Westendorp, Rudi G.J., Frölich, Marijke, de Craen, Anton J.M., Beekman, Marian, Heijmans, Bastiaan T., Mooijaart, Simon P., Blauw, Gerard-Jan, Slagboom, P. Eline, van Heemst, Diana, Group, on behalf of the Leiden Longevity Study (LLS)
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806046/
https://www.ncbi.nlm.nih.gov/pubmed/20157552
Descripción
Sumario:Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

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