PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism

BACKGROUND: Genetic analysis of the human prion protein gene (PRNP) in suspect cases of Creutzfeldt-Jakob disease (CJD) is necessary for accurate diagnosis and case classification. Previous publications on the genetic variation at the PRNP locus have highlighted the presence of numerous polymorphism...

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Detalles Bibliográficos
Autores principales: Bishop, Matthew T, Pennington, Catherine, Heath, Craig A, Will, Robert G, Knight, Richard SG
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806268/
https://www.ncbi.nlm.nih.gov/pubmed/20035629
http://dx.doi.org/10.1186/1471-2350-10-146

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