IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatm...

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Detalles Bibliográficos
Autores principales: Thompson, Leslie Michels, Aiken, Charity T., Kaltenbach, Linda S., Agrawal, Namita, Illes, Katalin, Khoshnan, Ali, Martinez-Vincente, Marta, Arrasate, Montserrat, O'Rourke, Jacqueline Gire, Khashwji, Hasan, Lukacsovich, Tamas, Zhu, Ya-Zhen, Lau, Alice L., Massey, Ashish, Hayden, Michael R., Zeitlin, Scott O., Finkbeiner, Steven, Green, Kim N., LaFerla, Frank M., Bates, Gillian, Huang, Lan, Patterson, Paul H., Lo, Donald C., Cuervo, Ana Maria, Marsh, J. Lawrence, Steffan, Joan S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806289/
https://www.ncbi.nlm.nih.gov/pubmed/20026656
http://dx.doi.org/10.1083/jcb.200909067

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