Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines

BACKGROUND: One of the major reasons for poor prognosis of pancreatic cancer is its high resistance to currently available chemotherapeutic agents. In recent years, focal adhesion kinase (FAK), a central molecule in extracellular matrix (ECM)/integrin-mediated signaling, has been thought to be a key...

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Detalles Bibliográficos
Autores principales: Huanwen, Wu, Zhiyong, Liang, Xiaohua, Shi, Xinyu, Ren, Kai, Wang, Tonghua, Liu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806309/
https://www.ncbi.nlm.nih.gov/pubmed/20021699
http://dx.doi.org/10.1186/1476-4598-8-125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806309/
https://www.ncbi.nlm.nih.gov/pubmed/20021699
http://dx.doi.org/10.1186/1476-4598-8-125

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