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From uncertainty to reward: BOLD characteristics differentiate signaling pathways
BACKGROUND: Reward value and uncertainty are represented by dopamine neurons in monkeys by distinct phasic and tonic firing rates. Knowledge about the underlying differential dopaminergic pathways is crucial for a better understanding of dopamine-related processes. Using functional magnetic resonanc...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806405/ https://www.ncbi.nlm.nih.gov/pubmed/20028546 http://dx.doi.org/10.1186/1471-2202-10-154 |
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author | Abler, Birgit Herrnberger, Bärbel Grön, Georg Spitzer, Manfred |
author_facet | Abler, Birgit Herrnberger, Bärbel Grön, Georg Spitzer, Manfred |
author_sort | Abler, Birgit |
collection | PubMed |
description | BACKGROUND: Reward value and uncertainty are represented by dopamine neurons in monkeys by distinct phasic and tonic firing rates. Knowledge about the underlying differential dopaminergic pathways is crucial for a better understanding of dopamine-related processes. Using functional magnetic resonance blood-oxygen level dependent (BOLD) imaging we analyzed brain activation in 15 healthy, male subjects performing a gambling task, upon expectation of potential monetary rewards at different reward values and levels of uncertainty. RESULTS: Consistent with previous studies, ventral striatal activation was related to both reward magnitudes and values. Activation in medial and lateral orbitofrontal brain areas was best predicted by reward uncertainty. Moreover, late BOLD responses relative to trial onset were due to expectation of different reward values and likely to represent phasic dopaminergic signaling. Early BOLD responses were due to different levels of reward uncertainty and likely to represent tonic dopaminergic signals. CONCLUSIONS: We conclude that differential dopaminergic signaling as revealed in animal studies is not only represented locally by involvement of distinct brain regions but also by distinct BOLD signal characteristics. |
format | Text |
id | pubmed-2806405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28064052010-01-14 From uncertainty to reward: BOLD characteristics differentiate signaling pathways Abler, Birgit Herrnberger, Bärbel Grön, Georg Spitzer, Manfred BMC Neurosci Research article BACKGROUND: Reward value and uncertainty are represented by dopamine neurons in monkeys by distinct phasic and tonic firing rates. Knowledge about the underlying differential dopaminergic pathways is crucial for a better understanding of dopamine-related processes. Using functional magnetic resonance blood-oxygen level dependent (BOLD) imaging we analyzed brain activation in 15 healthy, male subjects performing a gambling task, upon expectation of potential monetary rewards at different reward values and levels of uncertainty. RESULTS: Consistent with previous studies, ventral striatal activation was related to both reward magnitudes and values. Activation in medial and lateral orbitofrontal brain areas was best predicted by reward uncertainty. Moreover, late BOLD responses relative to trial onset were due to expectation of different reward values and likely to represent phasic dopaminergic signaling. Early BOLD responses were due to different levels of reward uncertainty and likely to represent tonic dopaminergic signals. CONCLUSIONS: We conclude that differential dopaminergic signaling as revealed in animal studies is not only represented locally by involvement of distinct brain regions but also by distinct BOLD signal characteristics. BioMed Central 2009-12-22 /pmc/articles/PMC2806405/ /pubmed/20028546 http://dx.doi.org/10.1186/1471-2202-10-154 Text en Copyright ©2009 Abler et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research article Abler, Birgit Herrnberger, Bärbel Grön, Georg Spitzer, Manfred From uncertainty to reward: BOLD characteristics differentiate signaling pathways |
title | From uncertainty to reward: BOLD characteristics differentiate signaling pathways |
title_full | From uncertainty to reward: BOLD characteristics differentiate signaling pathways |
title_fullStr | From uncertainty to reward: BOLD characteristics differentiate signaling pathways |
title_full_unstemmed | From uncertainty to reward: BOLD characteristics differentiate signaling pathways |
title_short | From uncertainty to reward: BOLD characteristics differentiate signaling pathways |
title_sort | from uncertainty to reward: bold characteristics differentiate signaling pathways |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806405/ https://www.ncbi.nlm.nih.gov/pubmed/20028546 http://dx.doi.org/10.1186/1471-2202-10-154 |
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