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Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells

The double-stranded RNA (dsRNA) analogue poly(I:C) is a promising adjuvant for cancer vaccines because it activates both dendritic cells (DCs) and natural killer (NK) cells, concurrently promoting adaptive and innate anticancer responses. Poly(I:C) acts through two dsRNA sensors, Toll-like receptor...

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Detalles Bibliográficos
Autores principales:	McCartney, Stephen, Vermi, William, Gilfillan, Susan, Cella, Marina, Murphy, Theresa L., Schreiber, Robert D., Murphy, Kenneth M., Colonna, Marco
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806445/ https://www.ncbi.nlm.nih.gov/pubmed/19995959 http://dx.doi.org/10.1084/jem.20091181

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