Bone marrow mesenchymal stem cells from infants with MLL-AF4(+) acute leukemia harbor and express the MLL-AF4 fusion gene

MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development is difficult to ascertain. The bone marrow (BM) microenvironment plays an important role in the pathogenesi...

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Detalles Bibliográficos
Autores principales: Menendez, Pablo, Catalina, Purificación, Rodríguez, René, Melen, Gustavo J., Bueno, Clara, Arriero, Mar, García-Sánchez, Félix, Lassaletta, Alvaro, García-Sanz, Ramón, García-Castro, Javier
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806455/
https://www.ncbi.nlm.nih.gov/pubmed/19995953
http://dx.doi.org/10.1084/jem.20091050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806455/
https://www.ncbi.nlm.nih.gov/pubmed/19995953
http://dx.doi.org/10.1084/jem.20091050

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