Mincle is a long sought receptor for mycobacterial cord factor

Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6’-dimycolate (TDM), a potent immunostimulant that...

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Detalles Bibliográficos
Autores principales: Matsunaga, Isamu, Moody, D. Branch
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806465/
https://www.ncbi.nlm.nih.gov/pubmed/20008525
http://dx.doi.org/10.1084/jem.20092533
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author Matsunaga, Isamu
Moody, D. Branch
author_facet Matsunaga, Isamu
Moody, D. Branch
author_sort Matsunaga, Isamu
collection PubMed
description Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6’-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design.
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spelling pubmed-28064652010-06-21 Mincle is a long sought receptor for mycobacterial cord factor Matsunaga, Isamu Moody, D. Branch J Exp Med Commentary Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6’-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design. The Rockefeller University Press 2009-12-21 /pmc/articles/PMC2806465/ /pubmed/20008525 http://dx.doi.org/10.1084/jem.20092533 Text en © 2009 Matsunaga and Moody This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Matsunaga, Isamu
Moody, D. Branch
Mincle is a long sought receptor for mycobacterial cord factor
title Mincle is a long sought receptor for mycobacterial cord factor
title_full Mincle is a long sought receptor for mycobacterial cord factor
title_fullStr Mincle is a long sought receptor for mycobacterial cord factor
title_full_unstemmed Mincle is a long sought receptor for mycobacterial cord factor
title_short Mincle is a long sought receptor for mycobacterial cord factor
title_sort mincle is a long sought receptor for mycobacterial cord factor
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806465/
https://www.ncbi.nlm.nih.gov/pubmed/20008525
http://dx.doi.org/10.1084/jem.20092533
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