Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

PI3K signaling is thought to mediate leptin and insulin action in hypothalamic pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, key regulators of energy homeostasis, through largely unknown mechanisms. We inactivated either p110α or p110β PI3K catalytic subunits in these neuron...

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Detalles Bibliográficos
Autores principales: Al-Qassab, Hind, Smith, Mark A., Irvine, Elaine E., Guillermet-Guibert, Julie, Claret, Marc, Choudhury, Agharul I., Selman, Colin, Piipari, Kaisa, Clements, Melanie, Lingard, Steven, Chandarana, Keval, Bell, Jimmy D., Barsh, Gregory S., Smith, Andrew J.H., Batterham, Rachel L., Ashford, Michael L.J., Vanhaesebroeck, Bart, Withers, Dominic J.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806524/
https://www.ncbi.nlm.nih.gov/pubmed/19883613
http://dx.doi.org/10.1016/j.cmet.2009.09.008

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