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Mutational analysis of molecular requirements for the actions of general anaesthetics at the γ-aminobutyric acid(A )receptor subtype, α1β2γ2

BACKGROUND: Amino acids in the β subunit contribute to the action of general anaesthetics on GABA(A )receptors. We have now characterized the phenotypic effect of two β subunit mutations in the most abundant GABA(A )receptor subtype, α1β2γ2. RESULTS: The β2(N265M) mutation in M2 decreased the modula...

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Detalles Bibliográficos
Autores principales:	Siegwart, Roberta, Krähenbühl, Karin, Lambert, Sachar, Rudolph, Uwe
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2003
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC280653/ https://www.ncbi.nlm.nih.gov/pubmed/14613517 http://dx.doi.org/10.1186/1471-2210-3-13

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