Cargando…

Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse

RATIONALE/OBJECTIVES: There is a high prevalence of substance use disorder (SUD) in first-episode schizophrenia (SZ), but its contribution to the underlying SZ pathophysiology remains unclear. Several studies using transcranial magnetic stimulation (TMS) have observed abnormalities in human motor co...

Descripción completa

Detalles Bibliográficos
Autores principales: Wobrock, Thomas, Hasan, Alkomiet, Malchow, Berend, Wolff-Menzler, Claus, Guse, Birgit, Lang, Nicolas, Schneider-Axmann, Thomas, Ecker, Ullrich K. H., Falkai, Peter
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806533/
https://www.ncbi.nlm.nih.gov/pubmed/19997844
http://dx.doi.org/10.1007/s00213-009-1736-8
_version_ 1782176316247769088
author Wobrock, Thomas
Hasan, Alkomiet
Malchow, Berend
Wolff-Menzler, Claus
Guse, Birgit
Lang, Nicolas
Schneider-Axmann, Thomas
Ecker, Ullrich K. H.
Falkai, Peter
author_facet Wobrock, Thomas
Hasan, Alkomiet
Malchow, Berend
Wolff-Menzler, Claus
Guse, Birgit
Lang, Nicolas
Schneider-Axmann, Thomas
Ecker, Ullrich K. H.
Falkai, Peter
author_sort Wobrock, Thomas
collection PubMed
description RATIONALE/OBJECTIVES: There is a high prevalence of substance use disorder (SUD) in first-episode schizophrenia (SZ), but its contribution to the underlying SZ pathophysiology remains unclear. Several studies using transcranial magnetic stimulation (TMS) have observed abnormalities in human motor cortex (M1) excitability in SZ. Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking. METHODS: A total of 29 first-episode SZ patients participated in this study; 12 had a history of comorbid cannabis abuse (SZ-SUD) and 17 did not (SZ-NSUD). We applied TMS to right and left M1 areas to assess the resting motor threshold (RMT), short-interval cortical inhibition (SICI), intracortical facilitation (ICF), and the contralateral cortical silent period (CSP). RESULTS: In SICI and ICF conditions, right M1 stimulation led to significantly higher motor evoked potential ratios in SZ-SUD compared to SZ-NSUD. This suggests lower cortical inhibition and increased ICF in first-episode SZ with previous cannabis abuse. There were no group differences in RMT and CSP duration. Neither were there any significant correlations between psychopathology (as indexed by Positive and Negative Syndrome Scale), disease characteristics, the extent of cannabis abuse, and TMS parameters (SICI, ICF, and CSP). CONCLUSIONS: Comorbid cannabis abuse may potentiate the reduced intracortical inhibition and enhanced ICF observed in first-episode SZ patients in some previous studies. This finding suggests an increased alteration of GABA(A) and NMDA receptor activity in cannabis-abusing first-episode patients as compared to schizophrenia patients with no history of substance abuse. This may constitute a distinct vulnerability factor in this special population.
format Text
id pubmed-2806533
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Springer-Verlag
record_format MEDLINE/PubMed
spelling pubmed-28065332010-01-22 Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse Wobrock, Thomas Hasan, Alkomiet Malchow, Berend Wolff-Menzler, Claus Guse, Birgit Lang, Nicolas Schneider-Axmann, Thomas Ecker, Ullrich K. H. Falkai, Peter Psychopharmacology (Berl) Original Investigation RATIONALE/OBJECTIVES: There is a high prevalence of substance use disorder (SUD) in first-episode schizophrenia (SZ), but its contribution to the underlying SZ pathophysiology remains unclear. Several studies using transcranial magnetic stimulation (TMS) have observed abnormalities in human motor cortex (M1) excitability in SZ. Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking. METHODS: A total of 29 first-episode SZ patients participated in this study; 12 had a history of comorbid cannabis abuse (SZ-SUD) and 17 did not (SZ-NSUD). We applied TMS to right and left M1 areas to assess the resting motor threshold (RMT), short-interval cortical inhibition (SICI), intracortical facilitation (ICF), and the contralateral cortical silent period (CSP). RESULTS: In SICI and ICF conditions, right M1 stimulation led to significantly higher motor evoked potential ratios in SZ-SUD compared to SZ-NSUD. This suggests lower cortical inhibition and increased ICF in first-episode SZ with previous cannabis abuse. There were no group differences in RMT and CSP duration. Neither were there any significant correlations between psychopathology (as indexed by Positive and Negative Syndrome Scale), disease characteristics, the extent of cannabis abuse, and TMS parameters (SICI, ICF, and CSP). CONCLUSIONS: Comorbid cannabis abuse may potentiate the reduced intracortical inhibition and enhanced ICF observed in first-episode SZ patients in some previous studies. This finding suggests an increased alteration of GABA(A) and NMDA receptor activity in cannabis-abusing first-episode patients as compared to schizophrenia patients with no history of substance abuse. This may constitute a distinct vulnerability factor in this special population. Springer-Verlag 2009-12-09 2010 /pmc/articles/PMC2806533/ /pubmed/19997844 http://dx.doi.org/10.1007/s00213-009-1736-8 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Investigation
Wobrock, Thomas
Hasan, Alkomiet
Malchow, Berend
Wolff-Menzler, Claus
Guse, Birgit
Lang, Nicolas
Schneider-Axmann, Thomas
Ecker, Ullrich K. H.
Falkai, Peter
Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
title Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
title_full Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
title_fullStr Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
title_full_unstemmed Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
title_short Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
title_sort increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806533/
https://www.ncbi.nlm.nih.gov/pubmed/19997844
http://dx.doi.org/10.1007/s00213-009-1736-8
work_keys_str_mv AT wobrockthomas increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT hasanalkomiet increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT malchowberend increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT wolffmenzlerclaus increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT gusebirgit increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT langnicolas increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT schneideraxmannthomas increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT eckerullrichkh increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse
AT falkaipeter increasedcorticalinhibitiondeficitsinfirstepisodeschizophreniawithcomorbidcannabisabuse