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Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region

Both class switch recombination (CSR) and somatic hypermutation (SHM) require transcription and the trans-acting factor activation-induced cytidine deaminase (AID), and must be up-regulated during antigen-dependent differentiation of B lymphocytes. To test the role of the heavy chain 3′ enhancers in...

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Detalles Bibliográficos
Autores principales:	Dunnick, Wesley A., Collins, John T., Shi, Jian, Westfield, Gerwin, Fontaine, Clinton, Hakimpour, Paul, Papavasiliou, F. Nina
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806627/ https://www.ncbi.nlm.nih.gov/pubmed/19887393 http://dx.doi.org/10.1084/jem.20091280

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