Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination

The H2AX core histone variant is phosphorylated in chromatin around DNA double strand breaks (DSBs) and functions through unknown mechanisms to suppress antigen receptor locus translocations during V(D)J recombination. Formation of chromosomal coding joins and suppression of translocations involves...

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Detalles Bibliográficos
Autores principales: Yin, Bu, Savic, Velibor, Juntilla, Marisa M., Bredemeyer, Andrea L., Yang-Iott, Katherine S., Helmink, Beth A., Koretzky, Gary A., Sleckman, Barry P., Bassing, Craig H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806628/
https://www.ncbi.nlm.nih.gov/pubmed/19887394
http://dx.doi.org/10.1084/jem.20091320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806628/
https://www.ncbi.nlm.nih.gov/pubmed/19887394
http://dx.doi.org/10.1084/jem.20091320

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