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Molecular footprints of a germinal center derivation of human IgM(+)(IgD(+))CD27(+) B cells and the dynamics of memory B cell generation
The origin of IgM(+)CD27(+) B lymphocytes with mutated IgV genes, which account for ∼20% of human peripheral blood (PB) B cells, is controversially discussed. A generation in a primary diversification pathway, in T cell–independent immune responses, or in T cell–dependent germinal center (GC) reacti...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806629/ https://www.ncbi.nlm.nih.gov/pubmed/19917772 http://dx.doi.org/10.1084/jem.20091087 |