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Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case
BACKGROUND: We attempt to ascertain if the 3 linked single nucleotide polymorphisms (SNPs) of the Progesterone Receptor (PR) gene (exon 1: G 1031 C; S344T, exon 4: G 1978 T; L660V and exon 5: C 2310 T; H770H) and the PROGINS insertion in the intron G, between exons 7 and 8, are associated with Recur...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806831/ https://www.ncbi.nlm.nih.gov/pubmed/20090851 http://dx.doi.org/10.1371/journal.pone.0008712 |
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author | Aruna, Meka Nagaraja, Theeya Andal, Sadaranga Tarakeswari, Surapaneni Sirisha, Pisapati V. S. Reddy, Alla G. Thangaraj, Kumarasamy Singh, Lalji Reddy, B. Mohan |
author_facet | Aruna, Meka Nagaraja, Theeya Andal, Sadaranga Tarakeswari, Surapaneni Sirisha, Pisapati V. S. Reddy, Alla G. Thangaraj, Kumarasamy Singh, Lalji Reddy, B. Mohan |
author_sort | Aruna, Meka |
collection | PubMed |
description | BACKGROUND: We attempt to ascertain if the 3 linked single nucleotide polymorphisms (SNPs) of the Progesterone Receptor (PR) gene (exon 1: G 1031 C; S344T, exon 4: G 1978 T; L660V and exon 5: C 2310 T; H770H) and the PROGINS insertion in the intron G, between exons 7 and 8, are associated with Recurrent Spontaneous Abortion (RSA) in the Indian population. METHODOLOGY/PRINCIPAL FINDINGS: A total of 143 women with RSA and 150 controls were sequenced for all the 8 exons looking for the above 3 linked SNPs of the PR gene earlier implicated in the RSA, as well as for any new SNPs that may be possibly found in the Indian population. PROGINS insertion was screened by electrophoresis. We did not find any new mutations, not observed earlier, in our population. Further, we did not find significant role of the *2 allele (representing the mutant allele at the three SNP loci) or the T2 allele (PROGINS insertion) in the manifestation of RSA. We also did not find an LD pattern between each of the 3 SNPs and the PROGINS insertion. CONCLUSIONS/SIGNIFICANCE: The results suggest that the PR gene mutations may not play any exclusive role in the manifestation of RSA, and instead, given significantly higher frequency of the *2 allele among the normal women, we surmise if it does not really confer a protective role among the Indian populations, albeit further studies are required in the heterogeneous populations of this region before making any conclusive statement. |
format | Text |
id | pubmed-2806831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28068312010-01-20 Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case Aruna, Meka Nagaraja, Theeya Andal, Sadaranga Tarakeswari, Surapaneni Sirisha, Pisapati V. S. Reddy, Alla G. Thangaraj, Kumarasamy Singh, Lalji Reddy, B. Mohan PLoS One Research Article BACKGROUND: We attempt to ascertain if the 3 linked single nucleotide polymorphisms (SNPs) of the Progesterone Receptor (PR) gene (exon 1: G 1031 C; S344T, exon 4: G 1978 T; L660V and exon 5: C 2310 T; H770H) and the PROGINS insertion in the intron G, between exons 7 and 8, are associated with Recurrent Spontaneous Abortion (RSA) in the Indian population. METHODOLOGY/PRINCIPAL FINDINGS: A total of 143 women with RSA and 150 controls were sequenced for all the 8 exons looking for the above 3 linked SNPs of the PR gene earlier implicated in the RSA, as well as for any new SNPs that may be possibly found in the Indian population. PROGINS insertion was screened by electrophoresis. We did not find any new mutations, not observed earlier, in our population. Further, we did not find significant role of the *2 allele (representing the mutant allele at the three SNP loci) or the T2 allele (PROGINS insertion) in the manifestation of RSA. We also did not find an LD pattern between each of the 3 SNPs and the PROGINS insertion. CONCLUSIONS/SIGNIFICANCE: The results suggest that the PR gene mutations may not play any exclusive role in the manifestation of RSA, and instead, given significantly higher frequency of the *2 allele among the normal women, we surmise if it does not really confer a protective role among the Indian populations, albeit further studies are required in the heterogeneous populations of this region before making any conclusive statement. Public Library of Science 2010-01-14 /pmc/articles/PMC2806831/ /pubmed/20090851 http://dx.doi.org/10.1371/journal.pone.0008712 Text en Aruna et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Aruna, Meka Nagaraja, Theeya Andal, Sadaranga Tarakeswari, Surapaneni Sirisha, Pisapati V. S. Reddy, Alla G. Thangaraj, Kumarasamy Singh, Lalji Reddy, B. Mohan Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case |
title | Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case |
title_full | Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case |
title_fullStr | Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case |
title_full_unstemmed | Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case |
title_short | Role of Progesterone Receptor Polymorphisms in the Recurrent Spontaneous Abortions: Indian Case |
title_sort | role of progesterone receptor polymorphisms in the recurrent spontaneous abortions: indian case |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806831/ https://www.ncbi.nlm.nih.gov/pubmed/20090851 http://dx.doi.org/10.1371/journal.pone.0008712 |
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