The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation

Mutations in the gene encoding Leucine-rich repeat kinase 2 (LRRK2) are the most common cause of inherited Parkinson's disease (PD). LRRK2 is a multi-domain protein kinase containing a central catalytic core and a number of protein-protein interaction domains. An important step forward in the u...

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Detalles Bibliográficos
Autores principales: Kumar, Azad, Greggio, Elisa, Beilina, Alexandra, Kaganovich, Alice, Chan, Diane, Taymans, Jean-Marc, Wolozin, Benjamin, Cookson, Mark R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806920/
https://www.ncbi.nlm.nih.gov/pubmed/20090955
http://dx.doi.org/10.1371/journal.pone.0008730

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