Cargando…

Generation of bovine transgenics using somatic cell nuclear transfer

The ability to produce transgenic animals through the introduction of exogenous DNA has existed for many years. However, past methods available to generate transgenic animals, such as pronuclear microinjection or the use of embryonic stem cells, have either been inefficient or not available in all a...

Descripción completa

Detalles Bibliográficos
Autores principales: Hodges, Craig A, Stice, Steven L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC280725/
https://www.ncbi.nlm.nih.gov/pubmed/14613543
http://dx.doi.org/10.1186/1477-7827-1-81
_version_ 1782121069890502656
author Hodges, Craig A
Stice, Steven L
author_facet Hodges, Craig A
Stice, Steven L
author_sort Hodges, Craig A
collection PubMed
description The ability to produce transgenic animals through the introduction of exogenous DNA has existed for many years. However, past methods available to generate transgenic animals, such as pronuclear microinjection or the use of embryonic stem cells, have either been inefficient or not available in all animals, bovine included. More recently somatic cell nuclear transfer has provided a method to create transgenic animals that overcomes many deficiencies present in other methods. This review summarizes the benefits of using somatic cell nuclear transfer to create bovine transgenics as well as the possible opportunities this method creates for the future.
format Text
id pubmed-280725
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-2807252003-12-02 Generation of bovine transgenics using somatic cell nuclear transfer Hodges, Craig A Stice, Steven L Reprod Biol Endocrinol Review The ability to produce transgenic animals through the introduction of exogenous DNA has existed for many years. However, past methods available to generate transgenic animals, such as pronuclear microinjection or the use of embryonic stem cells, have either been inefficient or not available in all animals, bovine included. More recently somatic cell nuclear transfer has provided a method to create transgenic animals that overcomes many deficiencies present in other methods. This review summarizes the benefits of using somatic cell nuclear transfer to create bovine transgenics as well as the possible opportunities this method creates for the future. BioMed Central 2003-11-07 /pmc/articles/PMC280725/ /pubmed/14613543 http://dx.doi.org/10.1186/1477-7827-1-81 Text en Copyright © 2003 Hodges and Stice; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Review
Hodges, Craig A
Stice, Steven L
Generation of bovine transgenics using somatic cell nuclear transfer
title Generation of bovine transgenics using somatic cell nuclear transfer
title_full Generation of bovine transgenics using somatic cell nuclear transfer
title_fullStr Generation of bovine transgenics using somatic cell nuclear transfer
title_full_unstemmed Generation of bovine transgenics using somatic cell nuclear transfer
title_short Generation of bovine transgenics using somatic cell nuclear transfer
title_sort generation of bovine transgenics using somatic cell nuclear transfer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC280725/
https://www.ncbi.nlm.nih.gov/pubmed/14613543
http://dx.doi.org/10.1186/1477-7827-1-81
work_keys_str_mv AT hodgescraiga generationofbovinetransgenicsusingsomaticcellnucleartransfer
AT sticestevenl generationofbovinetransgenicsusingsomaticcellnucleartransfer