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Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits

Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided into two groups of eight each consisting of either sex. Animals in group-...

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Autores principales: Pavithra, B. H., Prakash, N., Jayakumar, K.
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807264/
https://www.ncbi.nlm.nih.gov/pubmed/19934593
http://dx.doi.org/10.4142/jvs.2009.10.4.293
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author Pavithra, B. H.
Prakash, N.
Jayakumar, K.
author_facet Pavithra, B. H.
Prakash, N.
Jayakumar, K.
author_sort Pavithra, B. H.
collection PubMed
description Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided into two groups of eight each consisting of either sex. Animals in group-I were administered norfloxacin (100 mg/kg body weight p.o), while animals in group-II received similar dose of norfloxacin after pre-treatment with curcumin (60 mg/kg body weight per day, 3 days, p.o). Blood samples were drawn from the marginal ear vein into heparin-coated vials at 0 (zero time), 5, 10, 15, 30 min and 1, 2, 4, 6, 12 and 24 h post-treatment. Plasma norfloxacin concentrations were determined by high performance liquid chromatography. The plasma concentration-time profile of norfloxacin was adequately described by a one-compartment open model. The pharmacokinetic data revealed that curcumin-treated animals had significantly (p ≤ 0.05) higher area under the plasma concentration-time curve and area under the first moment of plasma drug concentration-time curve. Prior treatment of curcumin significantly (p ≤ 0.05) increased elimination half-life and volume of distribution of norfloxacin. Further treatment with curcumin reduced loading and maintenance doses by 26% and 24% respectively.
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spelling pubmed-28072642010-01-15 Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits Pavithra, B. H. Prakash, N. Jayakumar, K. J Vet Sci Original Article Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided into two groups of eight each consisting of either sex. Animals in group-I were administered norfloxacin (100 mg/kg body weight p.o), while animals in group-II received similar dose of norfloxacin after pre-treatment with curcumin (60 mg/kg body weight per day, 3 days, p.o). Blood samples were drawn from the marginal ear vein into heparin-coated vials at 0 (zero time), 5, 10, 15, 30 min and 1, 2, 4, 6, 12 and 24 h post-treatment. Plasma norfloxacin concentrations were determined by high performance liquid chromatography. The plasma concentration-time profile of norfloxacin was adequately described by a one-compartment open model. The pharmacokinetic data revealed that curcumin-treated animals had significantly (p ≤ 0.05) higher area under the plasma concentration-time curve and area under the first moment of plasma drug concentration-time curve. Prior treatment of curcumin significantly (p ≤ 0.05) increased elimination half-life and volume of distribution of norfloxacin. Further treatment with curcumin reduced loading and maintenance doses by 26% and 24% respectively. The Korean Society of Veterinary Science 2009-12 2009-11-26 /pmc/articles/PMC2807264/ /pubmed/19934593 http://dx.doi.org/10.4142/jvs.2009.10.4.293 Text en Copyright © 2009 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pavithra, B. H.
Prakash, N.
Jayakumar, K.
Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
title Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
title_full Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
title_fullStr Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
title_full_unstemmed Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
title_short Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
title_sort modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807264/
https://www.ncbi.nlm.nih.gov/pubmed/19934593
http://dx.doi.org/10.4142/jvs.2009.10.4.293
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